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EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

Raphael Weiss, Khaschayar Saadat-Gilani, Laura Kerschke, Carola Wempe, Melanie Meersch, Alexander Zarbock, Hichem Makhloufi, Anis Cherak, Lamine Lakhel Ghanem, Zohier Gouaglia, Dina Nasrine Guadouri, Fayrouz Naouel Hama, Mustafa Kara, Omayma Saadi, Rachida Sakhraoui, Fadila Bourou, Abdelhadi Cherifi, Rahmoune Ghania Sadaoui, Amel A Ouyahia, Ilhem OuahabSouad Bouaoud, Meriem Abdoun, Anisse Tidjane, Benali Tabeti, Nabil Boudjenan-Serradj, Carlos J. Perez Rivera, Paulo Cabrer, Julian Corso, Juan P. García Méndez, Sharon V. Idarraga-Ayala, Christopher Montoya, Rafael Figueroa-Casanova, Eduar Aldana, María Alejandra Torrado, Ke Peng, Zhengmin Ma, Yufan Yang, Yajuan Zhu, Peter Sklienka, Michal Frelich, Vojtech Jarkulis, Pavel Sevcik, Vojtech Vodicka, Mohamed Elbahnasawy, Shady Elsalhawy, Sara H. Motawea, Zeinab Othman, Mohamed Sahma, Ahmed Mahmoud Nafea, Nermin Ahmed, Doaa Ali Attia, Moataz Maher Emara, Mohamed Mamdouh Bonna, Mohamed Ahmed Gabr, Amany Ismail Tarbay, Ibrahim A. Abdehaleem, Esraa Elsayed Mohamed, Amr Mahmoud Eldeeb, Ahmed Mohamed Abbas, John Ashraf Magdy, Zyad Hassan Hamed, Hany Mostafa Esmaeil Osman, Mostafa Samy Abbas, Oliver Joannes-Boyau, Nicolas Barraud, Corentin Berthelot, Thibault Camus, Anissa Dahmi, Mylène Defaye, Sébastien Derville, Younes El-Boustani, Elsa Deloge, Hélène Jacob, Simon Monziols, Fred Priem, Jean-Jacques Robin, Vincent Legros, Therry Floch, Salvatore Muccio, Claire Geneve, Marie Lim Legouge, Stéphanie Tao Mauny, Willy Mfam, Léa Pascot, Christophe Aveline, Mireille Chartier, Benjamin Duteurtre, Jean Francois Gautier, Aidren Le Cousin, Pierre Vautier, Julien Nadaud, Nathalie Begel, Claire-Annissa Chekirine, Vincent Derlon, Elodie Grein, Marie-Annick Lehair, Laurent Magazzeni, Philippe Magazzeni, Carsten Potter, Catherine Roth, Florence Voivret, Thomas Rimmelé, Valérie Cerro, Stéphanie Suria, Jamie Elmawieh, Annabelle Stoclin, Cédric Cirenei, Gregoire Andrieu, Sven Couloumy, Jeremy Falcone, Marion Fajardy, Arsène Gagneuil, Emeline Girardet, Agnès Mazereeuw, Sébastien Ponsonnard, Pierre-Yves Egreteau, Mélanie Bertel, Simon Bocher, Vanessa Carn, Lenaïg Le Guen, Guillaume Le Loup, Montaine Lefevre, Carole Ichai, Amanita Diop, Vanessa Jean-Michel, Sylvie Devlieger, Juliette Duthoit, Mohamed El Kadiri, Maxime Léger, Viviane Cassisa, Sigismond Lasocki, Charline Masson, Emmanuel Rineau, Pierre Verrier, Axel Coquerel, Philippe Montravers, Enora Atchade, Charles-Edouard Rochon, Céline Delerue, Vidal Quentin, Vanessa Latry, Nina Queixalos, Vincent Cottenceau, Thierry Braun, Saad Bouzoubaa, Basile Christ, Audrey Geiger, Joachim Gomille, Vianney Kieffer, Simone Mangeant, Christelle Prochilo, Christian Schmitt, Stefan Skwirba, Hubert Grand, Frédérique Boury, Nicolas Mayeur, Marie Pasquie, Pierre Garçon, Vincent Bruckert, Vincent Arnould, Mona Bonciu, Thibault Chapelle, Luc Facchino, Florence Fagot-Gandet, Andrea Iachim, Elena Mannu, Olivier Perus, Rémi Plattier, Romain Rozier, Gaël Pradel, Michel Boudinaud, Marie-Hélène Hausermann, My Hue Nguyen, Andersen Ramorasata, Amélie Barreau, Anne-Hélène Boivin, Céline Ravry, Nicolas Mottard, Johanne Beuvelot, Florence Prunier Bossion, Olivier Desebbe, Christian Dörr, Thilo Caspar von Groote, Mira Küllmar, Christina Massoth, Sebastian Ziemann, Linda Grüßer, Ana Kowark, Pia Wittig, T. Brandenburger, Thomas Dimski, Niklas Döhmen, Laura Huthmann, Daniela Kaierle, Claude Pelletier, Manon Schleß, Andreas Hohn, S. Cleophas, S. Haunhorst, M. Jansen, A. Schmitt, J. Soisch, K. Sturm, P. Rosenberger, A. Bendig, L. Flohr, H. Häberle, Pascal Hofmann, Jens Kuhle, Nora Michaela Leser, K. Pfister, S. Prohaska, F. Sennholz, L. Stetz, K. Weber, S. Stehr, S. Klaus, M. Sadlo, M. Boschin, C. Sengelhoff, Ulrich Göbel, Jan Gerrit Haaker, Carina-Kristin Göttker, Matthias Gründel, M. Heringlake, R. Baumgärtel, A. Berggren, M. Gülzow, L. Muras, H. Paarmann, S. Thal, A. Bentley, D. El-Masri, A. Sebastiani, Eleni Arnaoutoglou, Maria Ntalouka, Paula Stratigopoulou, Analytis Analytis, Efthymios Mavrommatis, Petros Tzimas, Agathi Karakosta, Danai Pantazi, A. Dimakopoulou, K. Dimitropoulou, O. Ioannidis, H. Jalaawiy, A. Anwar, H.T. Hashim, H.I.R. Aldawoody, Andrea Cortegiani, G. Catalisano, G. Ingoglia, Mariachiara Ippolito, Silvia De Rosa, Lucia Cattin, A. Bianchin, M. Barone, G. Paternoster, Salvatore Lucio Cutuli, A. Russo, L. Sollazzi, Laura Cascarano, M. Antonelli, P. Aceto, B. Romanò, S. Spadaro, V.F. Tripodi, M. Rossi, R. Scappatura, M.C. Vadalà, Diego Fiume, M.T. Strano, G. Oddo, C. Santorsola, B.A. Hussain, Adnan Raed Alnaser, A.H. Ghassan, K. Hasanein, M. Theab, S. Shin, S. Jung, K. Lee, S.M. Jung, Jongyoon Baek, M.K. Elhadi, W.W.O. Aldressi, Issa A Abuzeid, M. Albaraesi, S. Aldressi, W. Khalel, Eman Abdulwahed, A.A.A. Abujrad, A. Almaghrabi, M.M. Alteleeb, E.A.A. Alshareea, M.I. Biala, A. Deeknah, D.A. Gheddim, R. Ghmagh, N.S.A.A. Ikhrays, M. Sinan, E. Soula, S.G. Bahroun, K. Derwish, A.M. Mohamed, E.S. Younes, Rayet Al Islam Benjouira, M. Aliwa, N.A. Altashani, M.O. Alteb, Ahmed Msherghi, Fatima Alagelli, Sufyan Albarouni, Ahmed Albishti, Sarah Aljamal, Mohamed Alsori, Taha Ekhuja, Suha Elzwai, Mohammed Ghula, Tahani Mustafa, Ahmed Tuwaib, Haifa Zriba, Hmza Mahmoud Agilla, Toky Andriamahefa Rafanomezantsoa, A.M.C. Podesta, D.M. Bonnici, T. Pirotta, G.A.G. López, M.M. Mijovska, T. Davitkovska, A. Gavrilovska, S. Lukikj, M. Vesova, D. Zafirova, Sarah Amro, B.N.F. Hajjaj, M. Alkhazendar, Y. Barakat, S.A. Elejla, A. Elhissi, A. Khader, A. Salem, R. de Freitas Regufe, A.F. de Oliveira Eloy, L.M.N.C. Perdigão, Evgeny Grigoryev, A. Ivkin, R. Kornelyuk, Michael Yaroustovsky, M. Abramyan, E. Komardina, N. Lesteva, M. Aybazova, E. Kumykova, S. Lesina, G. Rybakov, A. Shestov, A.A.A. Barmou, B.L.A. Ahmed, A.M. Eliyas, Y. Emadeldin, A. Kaserer, C. Castellucci, J. Rössler, S. Akbas, A.M. Petrun, I. Gregorcic, V. Sok, Roman Cicak, Elizabeth Bárcena, Antonio Guisado, Ismail Wi, Javier Ripollés-Melchor, Angel Becerra-Bolaños, Sergio Cabrera-Doreste, Ancor Domínguez-Arbelo, María Candelaria Delgado-Alonso, Virginia Muiño-Palomar, Aurelio Rodriguez-Perez, Javier Mata Estévez, Maria Begona Covas Munoz, Juan Mulet Matas, Sara Perez Palao, Maria Dolores Mira Quirós, Alisi Cezara Teslev, Marta Argilaga Nogués, Maria Campos, Albert Bainac Albadalejo, Astrid Batalla González, Mercedes García Álvarez, Marta Gine Serven, Gracia Herránz Perez, Ignacio Hinojal, Margarita Logroño Ejea, Noelia de la Rosa Ruiz, María Gastaca Abasolo, Carla Rosario Houhton Acuna, Ibai Iriarte Zaranton, Ana Mendigurenmurua, María José Munoz Sanz, Erika Olea de la Fuente, María Pilar Pérez Vaquero, Ana Soto Iglesias, Ana Ugarte Mieres, Alaitz Urtiaga Urrestizala, Lourdes Ferreira, Félix Lobato, Marta Aguado Sevilla, Andres Erazo, Pere Miró, Sergi Sabaté, Diana Vernetta, Anabel Adell Perez, Marta Aseguinolaza Pagola, Berta Castellano Paulis, Elena del Val Peciña, Ainhoa Garmendia Odriozola, Amaia Lopetegi Aizpurua, Olatz Pavón Piquer, Pilar Plou Garcia, P.O. Rezola, A.O. Lopez, I. de la Calle Gil, R.N. Casado, P. Adamove, R.B. Domenge, F.M.B. Blasco, A.A.R. Villamizar, M.A.P. Llaneras, J.I. García-Sánchez, L.F. Téllez, S.G. Zamorano, N.G. Herreros, A.R. Esteve, P.M. Rodríguez, I.G. Trigo, Agustín Alcaraz, A.L. Jiménez, Iñigo Rubio Baines, N. García, R. Callejas, A.M.C. Toha, E. Claros, P. Cobeta, P. Crespo, T. Dorado, Elena Elías, J. Felices, D. Gil, María Gómez, Nuria Mané, María Martín, Adolfo Martínez, Lucía Pereira, Alberto Balvis, Noemí Samaranch, Ana Serrano, Carlos Tiscar, Judith VillaHoz, Patricia Galán Menéndez, Elena Cardona, Anna Conesa, Verónica Estepa, Patricia Galán, Laura Llinares Espí, Yuri Santiago Loaiza Aldeán, Susana Manrique, Victor Morales Ariza, Laura Villarino Vila, E.S.M.A. Suliman, Hytham Hamid, Ahmed Mohamed Ibrahim, Modather Mohamed Saeed, Mukadder Orhan Sungur, Demet Altun, Nur Canbolat, Müserref Beril Dinçer, Özkan Tülay Seyhan, Serap Aktaş Yildirim, Müzeyyen Iyigün, Davut Yapici, Levent Özdemir, Aslinur Sagun, Neval Boztug, Yesim Cetintas, Bora Dinc, Emel Gündüz, Hakkı Ünlügenç, Demet Lafli Tunay, Deniz Karakaya, Burhan Dost, Ozgur Komurcu, Eren Fatma Akcil, Ozlem Korkmaz Dilmen, Yusuf Tunali, Gülay Ok, Eda Tok Alsina, Özge Hakli, Cengiz Polat, Namigar Turgut, Nurcan Kizilcik, Özge Köner, Öznur Sen, Nurdan Aydin, Burcu Basaran, Emre Sertac Bingul, Yavuz Gürkan, Kamil Darcin, Semra Ugur, Kemal Tolga Saracoglu, Asli Demir, Özgök Aysegül, Eda Balci, Behic Girgin, Aygun Guler, Ümit Karadeniz, Nihal Özaslan, Yigit Özay Hülya, Namik Ozcan, Aysun Postaci, Mehmet Sahap, Nevriye Salman, Özlem Sagir, Bulent Atik, Murat Bicakcioglu, Hafize Fisun Demir, Ugün Fatih, Nazan Kocaoglu, Hüseyin ilksen Toprak, Duygu Demiröz Aslan, Ziya Yusuf Colak, Mustafa Soner Ozcan, Mehmet Yilmaz, Umran Karaca, Sevtap Hekimoglu Sahin, Özlem Ersoy Karka, Gizem Demir Senoglu, Süheyla Erkoç Karadag, Neslihan Alkis, Volkan Baytas, Ali Akdogan, Ahmet Besir, Engin Erturk, Dilek Kutanis, Sedat Saylan, Ersagun Tugcugil, Pinar Ayvat, Berrin Günaydin, Beyza Mehri Büyükgebiz, Omer Faruk Boran, Feyza Calisir, Yavuz Orak, Bahar Kuvaki Balkan, Sibel Büyükcoban, Erol Gökel, Sakize Ferim Günenc, Sule Özbilgin, Suna Göre, Selcan Akesen, Seda Cansabuncu, Natalia Momot, Anna Panchenko, Jean-Francois Pittet, Kristen Rutledge

Research output: Contribution to journalArticleResearchpeer-review

Abstract

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369.
Original languageEnglish
JournalBMJ Open
Volume11
Issue number12
DOIs
Publication statusPublished - 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Adult intensive & critical care
  • Acute renal failure
  • Chronic renal failure
  • Epidemiology

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