Epidemiology of NMOSD in Catalonia: Influence of the new 2015 criteria in incidence and prevalence estimates

Maria Sepúlveda, Marta Aldea, Domingo Escudero, Sara Llufriu, Georgina Arrambide, Susana Otero-Romero, J. Sastre-Garriga, Lucía Romero-Pinel, Sergio Martínez-Yélamos, N. Sola-Valls, Thais Armangué, Javier Sotoca, Antonio Escartín, René Robles-Cedeño, Lluís Ramió-Torrentà, Silvia Presas-Rodríguez, Cristina Ramo-Tello, Elvira Munteis, Raúl Pelayo, Laura GubierasLuis Brieva, Nicolau Ortiz, Mariona Hervás, Maria Alba Mañé-Martínez, Antonio Cano, Emili Vela, Mar Tintoré, Yolanda Blanco, Xavier Montalban, Francesc Graus, Albert Saiz

Research output: Contribution to journalArticleResearch

50 Citations (Scopus)


© The Author(s), 2017. Background: Population-based studies on neuromyelitis optica spectrum disorders (NMOSD) are limited, and it is unclear whether the rates have changed with the implementation of the new 2015 criteria. Objectives: To estimate the incidence and prevalence of NMOSD in Catalonia (Spain), using both the 2006 and the 2015 criteria. Methods: In this clinic-based retrospective study, patients diagnosed with NMOSD between 2006 and 2015 were identified using multiple sources, including direct contact to all Catalan hospitals, identification of cases through the Catalan Health Surveillance System, and registry of antibodies to aquaporin-4 (AQP4-IgG) and myelin oligodendrocyte glycoprotein (MOG-IgG) in a reference laboratory. The incidence rate was calculated for the period 1 January 2006–1 January 2016 and prevalence for the date 1 January 2016. Results: We identified 74 patients (by the 2015 criteria). Most patients were Caucasian (81%), and female (76%) with a median age at disease onset of 42 years (range, 10–76 years). In total, 54 (73%) patients were positive for AQP4-IgG, 11 (15%) double-seronegative, and 9 (12%) MOG-IgG-positive. Rates of incidence and prevalence (0.63/1,000,000 person-years and 0.89/100,000, respectively) were 1.5-fold higher than those reported by the 2006 criteria. Lowest rates were seen in children and elder people and highest in women and middle-aged people (40–59 years). The female predominance was lost in incident AQP4-IgG-seronegative children and AQP4-IgG-positive elder people. MOG-IgG and double-seronegativity contributed similarly but did not influence the long-term outcome. Conclusion: The new criteria increase the estimates, but NMOSD remains as a rare disease. The differences in age- and sex-specific estimates highlight the importance of the serologic classification.
Original languageEnglish
Pages (from-to)1843-1851
JournalMultiple Sclerosis Journal
Publication statusPublished - 1 Dec 2018


  • AQP4-antibodies
  • incidence
  • MOG-antibodies
  • Neuromyelitis optica spectrum disorders
  • prevalence


Dive into the research topics of 'Epidemiology of NMOSD in Catalonia: Influence of the new 2015 criteria in incidence and prevalence estimates'. Together they form a unique fingerprint.

Cite this