TY - JOUR
T1 - Epidemiology and Risk Factors for Cancer After Lung Transplantation
AU - Berastegui, C.
AU - LaPorta, R.
AU - López-Meseguer, M.
AU - Romero, L.
AU - Gómez-Ollés, S.
AU - Riera, J.
AU - Monforte, V.
AU - Sáez, B.
AU - Bravo, C.
AU - Roman, A.
AU - Ussetti, P.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - © 2017 Cancer is the third most common cause of death among lung transplant (LT) recipients who survive for more than 1 year. The purpose of this study was to analyze the incidence and risk factors for cancer after LT in a Spanish cohort. The epidemiology and risk factors for cancer were retrospectively analyzed in LT recipients from 2 cities in Spain, Madrid and Barcelona. Of the 1353 LT patients initially included in the study, 125 (9.2%) developed cancer after a mean of 3.7 years. This frequency was 5-fold higher than in the general population. The most prevalent tumors were skin cancer (32%), lymphoproliferative disease (18%), and lung cancer (16.5%). In 4 patients, lung cancer was diagnosed on the day of the operation. The risk of cancer increased with age >55 year (hazard ratio [HR] 2.89 [1.64–5.09]; P <.001), in men (HR 2.8 [1.4–5.6]; P =.004), and in heavy smokers (>20 pack-years) (HR 2.94 [1.64–5.27]; P <.001). Other factors such as sun exposure were not found to be risk factors. In conclusion, prevalence of cancer is high in LT recipients in a Mediterranean country. Skin tumors, lymphoproliferative disease, and lung cancer are the most prevalent cancers. Age, male sex, and smoking were the main risk factors for cancer in this population.
AB - © 2017 Cancer is the third most common cause of death among lung transplant (LT) recipients who survive for more than 1 year. The purpose of this study was to analyze the incidence and risk factors for cancer after LT in a Spanish cohort. The epidemiology and risk factors for cancer were retrospectively analyzed in LT recipients from 2 cities in Spain, Madrid and Barcelona. Of the 1353 LT patients initially included in the study, 125 (9.2%) developed cancer after a mean of 3.7 years. This frequency was 5-fold higher than in the general population. The most prevalent tumors were skin cancer (32%), lymphoproliferative disease (18%), and lung cancer (16.5%). In 4 patients, lung cancer was diagnosed on the day of the operation. The risk of cancer increased with age >55 year (hazard ratio [HR] 2.89 [1.64–5.09]; P <.001), in men (HR 2.8 [1.4–5.6]; P =.004), and in heavy smokers (>20 pack-years) (HR 2.94 [1.64–5.27]; P <.001). Other factors such as sun exposure were not found to be risk factors. In conclusion, prevalence of cancer is high in LT recipients in a Mediterranean country. Skin tumors, lymphoproliferative disease, and lung cancer are the most prevalent cancers. Age, male sex, and smoking were the main risk factors for cancer in this population.
U2 - 10.1016/j.transproceed.2017.09.043
DO - 10.1016/j.transproceed.2017.09.043
M3 - Article
SN - 0041-1345
VL - 49
SP - 2285
EP - 2291
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 10
ER -
