Epidemiology and Risk Factors for Cancer After Lung Transplantation

C. Berastegui, R. LaPorta, M. López-Meseguer, L. Romero, S. Gómez-Ollés, J. Riera, V. Monforte, B. Sáez, C. Bravo, A. Roman, P. Ussetti

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

© 2017 Cancer is the third most common cause of death among lung transplant (LT) recipients who survive for more than 1 year. The purpose of this study was to analyze the incidence and risk factors for cancer after LT in a Spanish cohort. The epidemiology and risk factors for cancer were retrospectively analyzed in LT recipients from 2 cities in Spain, Madrid and Barcelona. Of the 1353 LT patients initially included in the study, 125 (9.2%) developed cancer after a mean of 3.7 years. This frequency was 5-fold higher than in the general population. The most prevalent tumors were skin cancer (32%), lymphoproliferative disease (18%), and lung cancer (16.5%). In 4 patients, lung cancer was diagnosed on the day of the operation. The risk of cancer increased with age >55 year (hazard ratio [HR] 2.89 [1.64–5.09]; P <.001), in men (HR 2.8 [1.4–5.6]; P =.004), and in heavy smokers (>20 pack-years) (HR 2.94 [1.64–5.27]; P <.001). Other factors such as sun exposure were not found to be risk factors. In conclusion, prevalence of cancer is high in LT recipients in a Mediterranean country. Skin tumors, lymphoproliferative disease, and lung cancer are the most prevalent cancers. Age, male sex, and smoking were the main risk factors for cancer in this population.
Original languageEnglish
Pages (from-to)2285-2291
JournalTransplantation Proceedings
Volume49
Issue number10
DOIs
Publication statusPublished - 1 Dec 2017

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