Epidemiology and outcome of candidaemia in patients with oncological and haematological malignancies: RESULTS from a population-based surveillance in Spain

M. Puig-Asensio, I. Ruiz-Camps, M. Fernández-Ruiz, J. M. Aguado, P. Muñoz, M. Valerio, A. Delgado-Iribarren, P. Merino, E. Bereciartua, J. Fortún, M. Cuenca-Estrella, B. Almirante, Belén Padilla, Patricia Muñoz, Jesús Guinea, José Ramón Paño, Julio García, Carlos García, Jesús Fortún, Pilar MartínElia Gómez, Pablo Ryan, Carolina Campelo, Ignacio de los Santos, Buenaventura Buendía, Beatriz Pérez, Mercedes Alonso, Francisca Sanz, J. M. Aguado, Paloma Merino, Fernando González, Miguel Gorgolas, Ignacio Gadea, Juan Emilio Losa, Alberto Delgado-Iribarren, Antonio Ramos, Yolanda Romero, Isabel Sánchez, Oscar Zaragoza, Manuel Cuenca-Estrella, Jesús Rodriguez-Baño, Ana Isabel Suarez, Ana Loza, Ana Isabel Aller, Estrella Martín-Mazuelos, Maite Ruiz, José Garnacho-Montero, Carlos Ortiz, Mónica Chávez, Fernando L. Maroto, Miguel Salavert, Javier Pemán, José Blanquer, David Navarro, Juan José Camarena, Rafael Zaragoza, Vicente Abril, Concepción Gimeno, Silvia Hernáez, Guillermo Ezpeleta, Elena Bereciartua, José L. Hernández, Miguel Montejo, Rosa Ana Rivas, Rafael Ayarza, Ana Planes, Benito Almirante, José Mensa, Manel Almela, Mercè Gurgui, Ferran Sánchez-Reus, Joaquin Martinez-Montauti, Montserrat Sierra, Juan Pablo Horcajada, Luisa Sorli, Julià Gómez, Amadeu Gené, Mireia Urrea

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Abstract

© 2015 European Society of Clinical Microbiology and Infectious Diseases. A prospective, population-based surveillance on candidaemia was implemented in five metropolitan areas of Spain from May 2010 to April 2011. We aimed to describe the distribution and susceptibility pattern of Candida species, and to evaluate risk factors for mortality in patients with oncological (solid tumours) and haematological malignancies. Adults (≥16 years) with cancer were included in the present report. Impact of therapeutic strategies on 7- and 30-day mortality were analysed by logistic regression, adjusting for propensity score by inverse weighting probability of receiving early antifungal treatment and catheter removal. We included 238 (32.6%) patients (195 oncological, 43 haematological). Compared with oncological patients, haematological patients were more likely to have received chemotherapy (53.5% versus 17.4%, p<0.001) or corticosteroids (41.9% versus 21%, p<0.001), and have neutropenia (44.2% versus 1.5%, p<0.001). Overall, 14.8% of patients developed breakthrough candidaemia. Non- albicans Candida species (71.1% versus 55.6%, p 0.056) and Candida tropicalis (22.2% versus 7.6%, p 0.011) were more frequent in haematological patients. Based on EUCAST breakpoints, 27.6% of Candida isolates were non-susceptible to fluconazole. Resistance to echinocandins was negligible. Mortality at 7 and 30 days was 12.2% and 31.5%, respectively, and did not differ significantly between the patient groups. Prompt antifungal therapy together with catheter removal (≤48 hours) was associated with lower mortality at 7 days (adjusted OR 0.05; 95% CI 0.01-0.42) and 30 days (adjusted OR 0.27; 95% CI 0.16-0.46). In conclusion, non- albicans species are emerging as the predominant isolates, particularly in haematological patients. Prompt, adequate antifungal treatment plus catheter removal may lead to a reduction in mortality.
Original languageEnglish
Pages (from-to)491.e1-491.e10
JournalClinical Microbiology and Infection
Volume21
Issue number5
DOIs
Publication statusPublished - 1 May 2015

Keywords

  • Antifungal agents
  • Cancer
  • Candidiasis
  • Drug resistance
  • Epidemiology
  • Fluconazole
  • Haematological malignancies

Fingerprint Dive into the research topics of 'Epidemiology and outcome of candidaemia in patients with oncological and haematological malignancies: RESULTS from a population-based surveillance in Spain'. Together they form a unique fingerprint.

Cite this