Enhanced molecular typing and macrolide and tetracycline-resistance mutations of Treponema pallidum in Barcelona

Candela Fernández-Naval, Maider Arando, Mateu Espasa, Andrés Antón, Miguel Fernández-Huerta, Aroa Silgado, Inmaculada Jimenez, Ana M. Villatoro, Juan J. González-López, Judit Serra-Pladevall, Elena Sulleiro, Tomàs Pumarola, Martí Vall-Mayans, Juliana Esperalba

Research output: Contribution to journalArticleResearch

3 Citations (Scopus)

Abstract

© 2019 Future Medicine Ltd. Aim: To describe the molecular types of Treponema pallidum and the proportion of macrolide and tetracycline resistance mutations in Barcelona. Materials & methods: Molecular type was determined using the Enhanced-CDC Typing system and antibiotic resistance was determined by sequencing the 23S and 16S rRNA genes. Results: A total of 183 patients were enrolled and 213 specimens (99 ulcers, 114 bloods) were collected. Sixty-Two (70.5%) of 88 ulcers and 0 (0%) of bloods T. pallidum-DNA containing samples were fully typed. Up to 21 different strain types were identified (14d/g in 27.4%; 14f/g in 14.5%). Macrolide resistance mutations were present in 95% and tetracycline in 0%. Conclusion: Several different strains co-exist in Barcelona with a high proportion of macrolide resistance and absence of tetracycline resistance.
Original languageEnglish
Pages (from-to)1099-1108
JournalFuture Microbiology
Volume14
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • ECDCT methodology
  • macrolide resistance
  • molecular typing
  • syphilis
  • tetracycline resistance
  • Treponema pallidum

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