Enhanced host-guest electrochemical recognition of dopamine using cyclodextrin in the presence of carbon nanotubes

G. Alarcón-Angeles; B. Pérez-López; M. Palomar-Pardave; M. T. Ramírez-Silva; S. Alegret; A. Merkoçi

doi:10.1016/j.carbon.2008.02.025

Enhanced host-guest electrochemical recognition of dopamine using cyclodextrin in the presence of carbon nanotubes

G. Alarcón-Angeles, B. Pérez-López, M. Palomar-Pardave, M. T. Ramírez-Silva, S. Alegret, A. Merkoçi

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

138 Citations (Scopus)

Abstract

A novel application of multiwall carbon nanotubes (MWCNT) for biosensor use is presented. β-Cyclodextrin (β-CD) as molecular receptor and MWCNT as enhancer of electron transfer are integrated in a dopamine (DA) electrochemical sensor system. The proposed molecular host-guest recognition based sensor has a high electrochemical sensitivity for the determination of DA. The electrochemical behaviour of DA is investigated by cyclic voltammetry (CV). The response mechanism of the MWCNT/β-CD modified electrode for DA is based on the combination of electrostatic and inclusion interaction of β-CD with DA which is distinguished from the response mechanism of non-modified electrode. The proposed integrated sensor showed improved analytical performance characteristics in catalytic oxidation of DA compared with non-modified electrode: excellent sensitivity, repeatability, stability, selectivity and recovery for the determination of DA. Under optimized conditions linear calibration plots were obtained for amperometric detection of DA over the range 0.01-0.08 mM. © 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	898-906
Journal	Carbon
Volume	46
Issue number	6
DOIs	https://doi.org/10.1016/j.carbon.2008.02.025
Publication status	Published - 1 May 2008

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title = "Enhanced host-guest electrochemical recognition of dopamine using cyclodextrin in the presence of carbon nanotubes",

abstract = "A novel application of multiwall carbon nanotubes (MWCNT) for biosensor use is presented. β-Cyclodextrin (β-CD) as molecular receptor and MWCNT as enhancer of electron transfer are integrated in a dopamine (DA) electrochemical sensor system. The proposed molecular host-guest recognition based sensor has a high electrochemical sensitivity for the determination of DA. The electrochemical behaviour of DA is investigated by cyclic voltammetry (CV). The response mechanism of the MWCNT/β-CD modified electrode for DA is based on the combination of electrostatic and inclusion interaction of β-CD with DA which is distinguished from the response mechanism of non-modified electrode. The proposed integrated sensor showed improved analytical performance characteristics in catalytic oxidation of DA compared with non-modified electrode: excellent sensitivity, repeatability, stability, selectivity and recovery for the determination of DA. Under optimized conditions linear calibration plots were obtained for amperometric detection of DA over the range 0.01-0.08 mM. {\textcopyright} 2008 Elsevier Ltd. All rights reserved.",

author = "G. Alarc{\'o}n-Angeles and B. P{\'e}rez-L{\'o}pez and M. Palomar-Pardave and Ram{\'i}rez-Silva, {M. T.} and S. Alegret and A. Merko{\c c}i",

year = "2008",

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doi = "10.1016/j.carbon.2008.02.025",

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T1 - Enhanced host-guest electrochemical recognition of dopamine using cyclodextrin in the presence of carbon nanotubes

AU - Alarcón-Angeles, G.

AU - Pérez-López, B.

AU - Palomar-Pardave, M.

AU - Ramírez-Silva, M. T.

AU - Alegret, S.

AU - Merkoçi, A.

PY - 2008/5/1

Y1 - 2008/5/1

N2 - A novel application of multiwall carbon nanotubes (MWCNT) for biosensor use is presented. β-Cyclodextrin (β-CD) as molecular receptor and MWCNT as enhancer of electron transfer are integrated in a dopamine (DA) electrochemical sensor system. The proposed molecular host-guest recognition based sensor has a high electrochemical sensitivity for the determination of DA. The electrochemical behaviour of DA is investigated by cyclic voltammetry (CV). The response mechanism of the MWCNT/β-CD modified electrode for DA is based on the combination of electrostatic and inclusion interaction of β-CD with DA which is distinguished from the response mechanism of non-modified electrode. The proposed integrated sensor showed improved analytical performance characteristics in catalytic oxidation of DA compared with non-modified electrode: excellent sensitivity, repeatability, stability, selectivity and recovery for the determination of DA. Under optimized conditions linear calibration plots were obtained for amperometric detection of DA over the range 0.01-0.08 mM. © 2008 Elsevier Ltd. All rights reserved.

AB - A novel application of multiwall carbon nanotubes (MWCNT) for biosensor use is presented. β-Cyclodextrin (β-CD) as molecular receptor and MWCNT as enhancer of electron transfer are integrated in a dopamine (DA) electrochemical sensor system. The proposed molecular host-guest recognition based sensor has a high electrochemical sensitivity for the determination of DA. The electrochemical behaviour of DA is investigated by cyclic voltammetry (CV). The response mechanism of the MWCNT/β-CD modified electrode for DA is based on the combination of electrostatic and inclusion interaction of β-CD with DA which is distinguished from the response mechanism of non-modified electrode. The proposed integrated sensor showed improved analytical performance characteristics in catalytic oxidation of DA compared with non-modified electrode: excellent sensitivity, repeatability, stability, selectivity and recovery for the determination of DA. Under optimized conditions linear calibration plots were obtained for amperometric detection of DA over the range 0.01-0.08 mM. © 2008 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.carbon.2008.02.025

DO - 10.1016/j.carbon.2008.02.025

M3 - Article

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EP - 906

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SN - 0008-6223

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