Enhanced gamma interferon responses of mouse spleen cells following immunotherapy for tuberculosis relapse

Olga Gil, Cristina Vilaplana, Evelyn Guirado, Jorge Díaz, Neus Cáceres, Mahavir Singh, Pere Joan Cardona

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Gamma interferon responses of spleen cells in mice were examined during postchemotherapy relapse of intraperitoneally induced latent tuberculous infection. The mycobacterial extract RUTI, which prevented the relapse, significantly enhanced the immune responses to secreted and structural recombinant mycobacterial antigens, suggesting that RUTI-mediated protection was mediated by activated T cells. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)1742-1744
JournalClinical and Vaccine Immunology
Volume15
Issue number11
DOIs
Publication statusPublished - 1 Nov 2008

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