Enhanced binding of [3H] (‐) adrenaline to platelets of depressed patients with melancholia: Effect of long‐term clomipramine treatment

J. A. Garcia‐Sevilla, C. Udina, M. J. Fuster, E. Alvarez, M. Casas

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Abstract

ABSTRACT— The specific binding of the full agonist [3H] (‐) adrenaline to platelet membranes was measured in 14 drug‐free depressed patients with melancholia. There was an increased number of binding sites (Bmax) with the same apparent affinity (KD) for the radioligand, indicating that platelet α2‐adrenoceptor density in the high affinity state was increased in depressed patients. Long‐term administration of clomipramine was associated with decreases in platelet α2‐adrenoceptor densities which correlated with the duration of treatment. The results support the hypothesis that in endogenous depression there is a dysfunction of the α2‐adrenoceptor and that antidepressant treatment might involve a time‐dependent desensitization process of this receptor. Copyright © 1987, Wiley Blackwell. All rights reserved
Original languageEnglish
Pages (from-to)150-157
JournalActa Psychiatrica Scandinavica
Volume75
Issue number2
DOIs
Publication statusPublished - 1 Jan 1987

Keywords

  • adrenaline
  • clomipramine
  • major depressive disorder
  • platelet adrenoceptors

Fingerprint Dive into the research topics of 'Enhanced binding of [<sup>3</sup>H] (‐) adrenaline to platelets of depressed patients with melancholia: Effect of long‐term clomipramine treatment'. Together they form a unique fingerprint.

Cite this