Engineered nonviral nanocarriers for intracellular gene delivery applications

Isaac Ojea-Jiménez, Olivia Tort, Julia Lorenzo, Victor F. Puntes

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

The efficient delivery of nucleic acids into mammalian cells is a central aspect of cell biology and of medical applications, including cancer therapy and tissue engineering. Non-viral chemical methods have been received with great interest for transfecting cells. However, further development of nanocarriers that are biocompatible, efficient and suitable for clinical applications is still required. In this paper, the different material platforms for gene delivery are comparatively addressed, and the mechanisms of interaction with biological systems are discussed carefully. © 2012 IOP Publishing Ltd.
Original languageEnglish
Article number054106
JournalBiomedical Materials (Bristol)
Volume7
DOIs
Publication statusPublished - 1 Jan 2012

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