Enantioselective synthesis of novel, highly conformationally constrained peptide surrogates

Miguel Díaz; José M. Jiménez; Rosa M. Ortuño

doi:10.1016/S0957-4166(97)00265-6

Enantioselective synthesis of novel, highly conformationally constrained peptide surrogates

Miguel Díaz, José M. Jiménez, Rosa M. Ortuño

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

26 Citations (Scopus)

Abstract

Two new enantiomeric peptide surrogates as well as a tripeptide, all of them having highly conformationally constrained structures, have been synthesized. (Z)-cyclo-Aspartic acid and convenient α-substituted isoserine derivatives, in both antipodal forms, as well as methyl (R)-2-phenylglycinate, have been used as the monomeric units.

Original language	English
Pages (from-to)	2465-2471
Journal	Tetrahedron Asymmetry
Volume	8
Issue number	14
DOIs	https://doi.org/10.1016/S0957-4166(97)00265-6
Publication status	Published - 24 Jul 1997

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title = "Enantioselective synthesis of novel, highly conformationally constrained peptide surrogates",

abstract = "Two new enantiomeric peptide surrogates as well as a tripeptide, all of them having highly conformationally constrained structures, have been synthesized. (Z)-cyclo-Aspartic acid and convenient α-substituted isoserine derivatives, in both antipodal forms, as well as methyl (R)-2-phenylglycinate, have been used as the monomeric units.",

author = "Miguel D{\'i}az and Jim{\'e}nez, {Jos{\'e} M.} and Ortu{\~n}o, {Rosa M.}",

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AU - Díaz, Miguel

AU - Jiménez, José M.

AU - Ortuño, Rosa M.

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Y1 - 1997/7/24

N2 - Two new enantiomeric peptide surrogates as well as a tripeptide, all of them having highly conformationally constrained structures, have been synthesized. (Z)-cyclo-Aspartic acid and convenient α-substituted isoserine derivatives, in both antipodal forms, as well as methyl (R)-2-phenylglycinate, have been used as the monomeric units.

AB - Two new enantiomeric peptide surrogates as well as a tripeptide, all of them having highly conformationally constrained structures, have been synthesized. (Z)-cyclo-Aspartic acid and convenient α-substituted isoserine derivatives, in both antipodal forms, as well as methyl (R)-2-phenylglycinate, have been used as the monomeric units.

U2 - 10.1016/S0957-4166(97)00265-6

DO - 10.1016/S0957-4166(97)00265-6

M3 - Article

VL - 8

SP - 2465

EP - 2471

IS - 14

ER -

Enantioselective synthesis of novel, highly conformationally constrained peptide surrogates

Abstract

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