© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Regio- and stereoselective oxyamination of dienes through a tandem rhodium-catalysed aziridination–nucleophilic opening affords racemic oxazolidinone derivatives, which undergo a kinetic resolution acylation process with amidine-based catalysts (ABCs) to achieve s values of up to 117. This protocol was applied to the enantioselective synthesis of sphingosine.
|Journal||Chemistry - A European Journal|
|Publication status||Published - 26 Mar 2018|
- kinetic resolution
- synthesis design