Enantioselective esterification of 2-arylpropionic acids and trans-2-phenyl-1-cyclohexanol: Comparison between immobilised lipases from Candida rugosa and Rhizomucor miehei

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Abstract

2-Phenyl propionic acid, ibuprofen and trans-2-phenyl-1-cyclohexanol were resolved using commercial Rhizomucor miehei lipase (Lipozyme IM20) and Candida rugosa lipase produced in our laboratory immobilised on EP100 polypropylene powder. Important differences were found on the enantioselectivity of both lipases in esterification reactions. Candida rugosa lipase was more enantioselective in the resolution of the tested substrates, especially with trans-2-phenyl-1-cyclohexanol, whereas the lipase from Rhizomucor miehei did not show catalytic activity with this substrate.
Original languageEnglish
Pages (from-to)1145-1148
JournalBiotechnology Letters
Volume20
DOIs
Publication statusPublished - 1 Dec 1998

Keywords

  • 2-Phenyl propionic acid
  • Candida rugosa and Rhizomucor miehei lipases
  • Enantioselectivity
  • Esterification
  • Ibuprofen
  • trans-2-Phenyl-1-cyclohexanol

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