Syntheses of (S)-β-angelica lactone from L-tartaric acid and (R)-γ-hydroxy-methyl-γ-butyrolactone, 5, are reported. Alternative routes to prepare 5 from S- and R-glutamic acids and D-ribonolactone, respectively, are also presented. Epoxides derived from (R)- and (S)-β-angelica lactones have been obtained and their use in the synthesis of both (+)- and (-)-blastmycinone, 24, has been established. © 1987.
Ortuño, R. M., Alonso, D., Cardellach, J., & Font, J. (1987). Enantiomeric β-angelica lactone epoxides: their syntheses from suitable chiral precursors and their use in the preparation of blastmycinone. Tetrahedron, 43(9), 2191-2198. https://doi.org/10.1016/S0040-4020(01)86801-0