An enantiodivergent synthesis of several cyclohexenyl nucleosides has been efficiently completed starting from the enantiopure hydrobenzoin-derived monoketal of cyclohex-2-en-1,4-dione, (+)-5. Stereodiversity was accomplished on the base coupling step. This methodology has proved to be useful for the synthesis of enantiopure pyrimidine and purine nucleoside analogues, which anti-HIV activity has been evaluated. © 2009 American Chemical Society.
|Journal||Journal of Organic Chemistry|
|Publication status||Published - 20 Mar 2009|
Ferrer, È., Alibés, R., Busqué, F., Figueredo, M., Font, J., & De March, P. (2009). Enantiodivergent synthesis of cyclohexenyl nucleosides. Journal of Organic Chemistry, 74(6), 2425-2432. https://doi.org/10.1021/jo802492g