Enantiodifferentiation through frequency-selective pure-shift 1H nuclear magnetic resonance spectroscopy

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A frequency-selective 1D 1H nuclear magnetic resonance (NMR) experiment for the fast and sensitive determination of chemical-shift differences between overlapped resonances is proposed. The resulting fully homodecoupled 1H NMR resonances appear as resolved 1D singlets without their typical J(HH) coupling constant multiplet structures. The high signal dispersion that is achieved is then exploited in enantiodiscrimination studies by using chiral solvating agents. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)854-857
Issue number5
Publication statusPublished - 4 Apr 2014


  • chemical shift
  • enantioselectivity
  • homodecoupling
  • nmr spectroscopy
  • single pulsed-field-gradient echo


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