Enantiodifferentiation through frequency-selective pure-shift 1H nuclear magnetic resonance spectroscopy

Laura Castañar, Míriam Pérez-Trujillo, Pau Nolis, Eva Monteagudo, Albert Virgili, Teodor Parella

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Abstract

A frequency-selective 1D 1H nuclear magnetic resonance (NMR) experiment for the fast and sensitive determination of chemical-shift differences between overlapped resonances is proposed. The resulting fully homodecoupled 1H NMR resonances appear as resolved 1D singlets without their typical J(HH) coupling constant multiplet structures. The high signal dispersion that is achieved is then exploited in enantiodiscrimination studies by using chiral solvating agents. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)854-857
JournalChemPhysChem
Volume15
Issue number5
DOIs
Publication statusPublished - 4 Apr 2014

Keywords

  • chemical shift
  • enantioselectivity
  • homodecoupling
  • nmr spectroscopy
  • single pulsed-field-gradient echo

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