Enantiodifferentiation through frequency-selective pure-shift 1H nuclear magnetic resonance spectroscopy

Laura Castañar; Míriam Pérez-Trujillo; Pau Nolis; Eva Monteagudo; Albert Virgili; Teodor Parella

doi:10.1002/cphc.201301130

Enantiodifferentiation through frequency-selective pure-shift ¹H nuclear magnetic resonance spectroscopy

Laura Castañar, Míriam Pérez-Trujillo, Pau Nolis, Eva Monteagudo, Albert Virgili, Teodor Parella

Research output: Contribution to journal › Article › Research › peer-review

38 Citations (Scopus)

Abstract

A frequency-selective 1D 1H nuclear magnetic resonance (NMR) experiment for the fast and sensitive determination of chemical-shift differences between overlapped resonances is proposed. The resulting fully homodecoupled 1H NMR resonances appear as resolved 1D singlets without their typical J(HH) coupling constant multiplet structures. The high signal dispersion that is achieved is then exploited in enantiodiscrimination studies by using chiral solvating agents. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Pages (from-to)	854-857
Journal	ChemPhysChem
Volume	15
Issue number	5
DOIs	https://doi.org/10.1002/cphc.201301130
Publication status	Published - 4 Apr 2014

Keywords

chemical shift
enantioselectivity
homodecoupling
nmr spectroscopy
single pulsed-field-gradient echo

Access to Document

10.1002/cphc.201301130

Cite this

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title = "Enantiodifferentiation through frequency-selective pure-shift 1H nuclear magnetic resonance spectroscopy",

abstract = "A frequency-selective 1D 1H nuclear magnetic resonance (NMR) experiment for the fast and sensitive determination of chemical-shift differences between overlapped resonances is proposed. The resulting fully homodecoupled 1H NMR resonances appear as resolved 1D singlets without their typical J(HH) coupling constant multiplet structures. The high signal dispersion that is achieved is then exploited in enantiodiscrimination studies by using chiral solvating agents. {\textcopyright} 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

keywords = "chemical shift, enantioselectivity, homodecoupling, nmr spectroscopy, single pulsed-field-gradient echo",

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T1 - Enantiodifferentiation through frequency-selective pure-shift 1H nuclear magnetic resonance spectroscopy

AU - Castañar, Laura

AU - Pérez-Trujillo, Míriam

AU - Nolis, Pau

AU - Monteagudo, Eva

AU - Virgili, Albert

AU - Parella, Teodor

PY - 2014/4/4

Y1 - 2014/4/4

N2 - A frequency-selective 1D 1H nuclear magnetic resonance (NMR) experiment for the fast and sensitive determination of chemical-shift differences between overlapped resonances is proposed. The resulting fully homodecoupled 1H NMR resonances appear as resolved 1D singlets without their typical J(HH) coupling constant multiplet structures. The high signal dispersion that is achieved is then exploited in enantiodiscrimination studies by using chiral solvating agents. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - A frequency-selective 1D 1H nuclear magnetic resonance (NMR) experiment for the fast and sensitive determination of chemical-shift differences between overlapped resonances is proposed. The resulting fully homodecoupled 1H NMR resonances appear as resolved 1D singlets without their typical J(HH) coupling constant multiplet structures. The high signal dispersion that is achieved is then exploited in enantiodiscrimination studies by using chiral solvating agents. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KW - chemical shift

KW - enantioselectivity

KW - homodecoupling

KW - nmr spectroscopy

KW - single pulsed-field-gradient echo

U2 - 10.1002/cphc.201301130

DO - 10.1002/cphc.201301130

M3 - Article

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VL - 15

SP - 854

EP - 857

JO - ChemPhysChem

JF - ChemPhysChem

IS - 5

ER -