Electrophoretic behaviour of pharmacologically active alkylxanthines

Marcelo Blanco, Ismael Valverde

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13 Citations (Scopus)


The electrophoretic behaviour of ionizable and neutral alkylxanthines commonly used in pharmaceutical preparations was studied. The performance of various separation modes including capillary zone electrophoresis (CZE), cyclodextrin electrokinetic chromatography, and micellar electrokinetic chromatography (MEKC) with either sodium dodecyl sulfate (SDS) or bile salts as surfactants, was assessed. CZE in an alkaline medium successfully separates ionizable xanthines and dyphylline. The addition of carboxymethyl-β-cyclodextrin to the background electrolyte allows only partial resolution of neutral xanthines. Based on MEKC results, bile salts exhibit more discrimination ability than SDS to separate similar xanthines. The best results are provided by taurodeoxycholic acid, which ensures baseline separation of xanthines. © 2002 Published by Elsevier Science B.V.
Original languageEnglish
Pages (from-to)293-299
JournalJournal of Chromatography
Issue number1-2
Publication statusPublished - 15 Mar 2002


  • Alkylxanthines
  • Pharmaceutical analysis
  • Surfactants
  • Xanthines


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