Electrochemical synthesis of nitroaromatic ketones

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Nitroaromatic ketones are readily prepared by nucleophilic aromatic substitution of hydrogen in nitroarenes by electrochemical oxidation. Carbanions of various ketones were added to selected nitroarenes in DMF/ketone mixtures leading to formation of the o11 complexes. The reaction was promoted using potassium feri-butoxide as a base. Useful yields were achieved (80-100%) in the C-arylation of ketones. In most cases, the process proceeded with high selectivity. This new method represents an environmentally favourable route for obtaining nitroaromatic ketones. © WILEY-VCH Verlag GmbH, 2002.
Original languageEnglish
Pages (from-to)261-267
JournalEuropean Journal of Organic Chemistry
Volume2
Issue number2
DOIs
Publication statusPublished - 1 Jan 2002

Keywords

  • Electrochemistry
  • Ketones
  • Nucleophilic substitution
  • Oxidations

Fingerprint

Dive into the research topics of 'Electrochemical synthesis of nitroaromatic ketones'. Together they form a unique fingerprint.

Cite this