Abstract
Nitroaromatic ketones are readily prepared by nucleophilic aromatic substitution of hydrogen in nitroarenes by electrochemical oxidation. Carbanions of various ketones were added to selected nitroarenes in DMF/ketone mixtures leading to formation of the o11 complexes. The reaction was promoted using potassium feri-butoxide as a base. Useful yields were achieved (80-100%) in the C-arylation of ketones. In most cases, the process proceeded with high selectivity. This new method represents an environmentally favourable route for obtaining nitroaromatic ketones. © WILEY-VCH Verlag GmbH, 2002.
Original language | English |
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Pages (from-to) | 261-267 |
Journal | European Journal of Organic Chemistry |
Volume | 2 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Jan 2002 |
Keywords
- Electrochemistry
- Ketones
- Nucleophilic substitution
- Oxidations