Electrochemical synthesis of nitroaromatic ketones

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25 Citations (Scopus)


Nitroaromatic ketones are readily prepared by nucleophilic aromatic substitution of hydrogen in nitroarenes by electrochemical oxidation. Carbanions of various ketones were added to selected nitroarenes in DMF/ketone mixtures leading to formation of the o11 complexes. The reaction was promoted using potassium feri-butoxide as a base. Useful yields were achieved (80-100%) in the C-arylation of ketones. In most cases, the process proceeded with high selectivity. This new method represents an environmentally favourable route for obtaining nitroaromatic ketones. © WILEY-VCH Verlag GmbH, 2002.
Original languageEnglish
Pages (from-to)261-267
JournalEuropean Journal of Organic Chemistry
Issue number2
Publication statusPublished - 1 Jan 2002


  • Electrochemistry
  • Ketones
  • Nucleophilic substitution
  • Oxidations


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