Electrocarboxylation of 1-chloro-(4-isobutylphenyl)ethane with a silver cathode in ionic liquids: An environmentally benign and efficient way to synthesize Ibuprofen

Silvia Mena, Jessica Sanchez, Gonzalo Guirado

Research output: Contribution to journalArticleResearch

5 Citations (Scopus)

Abstract

© 2019 The Royal Society of Chemistry. Electrocarboxylation of organic halides is one of the most widely used approaches for valorising CO2. In this manuscript, we report a new greener synthetic route for synthesising 2-(4-isobutylphenyl)propanoic acid, Ibuprofen, one of the most popular non-steroidal anti-inflammatory drugs (NSAIDs). The joint use of electrochemical techniques and ionic liquids (ILs) allows CO2 to be used as a C1-organic building block for synthesising Ibuprofen in high yields, with conversion ratios close to 100%, and under mild conditions. Furthermore, the determination of the reduction peak potential values of 1-chloro-(4-isobutylphenyl)ethane in several electrolytes (DMF, and ionic liquids) and with different cathodes (carbon and silver) makes it possible to evaluate the most "energetically" favourable conditions for performing the electrocarboxylation reaction. Hence, the use of ILs not only makes the electrolytic media greener, but they also act as catalysts enabling the electrochemical reduction of 1-chloro-(4-isobutylphenyl)ethane to be decreased by up to 1.0 V.
Original languageEnglish
Pages (from-to)15115-15123
JournalRSC Advances
Volume9
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint Dive into the research topics of 'Electrocarboxylation of 1-chloro-(4-isobutylphenyl)ethane with a silver cathode in ionic liquids: An environmentally benign and efficient way to synthesize Ibuprofen'. Together they form a unique fingerprint.

Cite this