Abstract
A convenient synthesis of the title nitrone is reported. The sequence starts from ethyl L-pyroglutamate as the source of chirality and the key step is the generation of an unstable α-methoxy-N-carboxylate ion, which readily decomposes to an imine. The oxidation of the imine with methyl(trifluoromethyl)dioxirane provides the enantiopure nitrone, which is trapped with dimethyl acetylenedicarboxylate. © 2002 Elsevier Science Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 437-445 |
Journal | Tetrahedron Asymmetry |
Volume | 13 |
Issue number | 4 |
DOIs | |
Publication status | Published - 22 Mar 2002 |