Efficient γ-amino-proline-derived cell penetrating peptide-superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents

Silvia Cavalli; Daniel Carbajo; Milena Acosta; S. Lope-Piedrafita; Ana Paula Candiota; Carles Arús; Miriam Royo; Fernando Albericio

doi:https://doi.org/10.1039/c2cc17937g

Efficient γ-amino-proline-derived cell penetrating peptide-superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents

Silvia Cavalli, Daniel Carbajo, Milena Acosta, S. Lope-Piedrafita, Ana Paula Candiota, Carles Arús, Miriam Royo, Fernando Albericio

Research output: Contribution to journal › Article › Research › peer-review

22 Citations (Scopus)

Abstract

Aniline-catalyzed oxime chemistry was employed to conjugate a γ-amino-proline-derived cell penetrating peptide to superparamagnetic iron oxide nanoparticles (SPIONs). Internalization of the novel nanoconjugate into HeLa cells was found to be remarkably higher compared to the analogous TAT-SPION conjugate. © 2012 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	5322-5324
Journal	Chemical Communications
Volume	48
DOIs	https://doi.org/10.1039/c2cc17937g
Publication status	Published - 28 May 2012

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Cavalli, S., Carbajo, D., Acosta, M., Lope-Piedrafita, S., Candiota, A. P., Arús, C., Royo, M., & Albericio, F. (2012). Efficient γ-amino-proline-derived cell penetrating peptide-superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents. Chemical Communications, 48, 5322-5324. https://doi.org/10.1039/c2cc17937g

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title = "Efficient γ-amino-proline-derived cell penetrating peptide-superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents",

abstract = "Aniline-catalyzed oxime chemistry was employed to conjugate a γ-amino-proline-derived cell penetrating peptide to superparamagnetic iron oxide nanoparticles (SPIONs). Internalization of the novel nanoconjugate into HeLa cells was found to be remarkably higher compared to the analogous TAT-SPION conjugate. {\textcopyright} 2012 The Royal Society of Chemistry.",

author = "Silvia Cavalli and Daniel Carbajo and Milena Acosta and S. Lope-Piedrafita and Candiota, {Ana Paula} and Carles Ar{\'u}s and Miriam Royo and Fernando Albericio",

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Cavalli, S, Carbajo, D, Acosta, M, Lope-Piedrafita, S , Candiota, AP , Arús, C, Royo, M & Albericio, F 2012, 'Efficient γ-amino-proline-derived cell penetrating peptide-superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents', Chemical Communications, vol. 48, pp. 5322-5324. https://doi.org/10.1039/c2cc17937g

Efficient γ-amino-proline-derived cell penetrating peptide-superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents. / Cavalli, Silvia; Carbajo, Daniel; Acosta, Milena et al.

In: Chemical Communications, Vol. 48, 28.05.2012, p. 5322-5324.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Cavalli, Silvia

AU - Carbajo, Daniel

AU - Acosta, Milena

AU - Lope-Piedrafita, S.

AU - Candiota, Ana Paula

AU - Arús, Carles

AU - Royo, Miriam

AU - Albericio, Fernando

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AB - Aniline-catalyzed oxime chemistry was employed to conjugate a γ-amino-proline-derived cell penetrating peptide to superparamagnetic iron oxide nanoparticles (SPIONs). Internalization of the novel nanoconjugate into HeLa cells was found to be remarkably higher compared to the analogous TAT-SPION conjugate. © 2012 The Royal Society of Chemistry.

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DO - https://doi.org/10.1039/c2cc17937g

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ER -

Efficient γ-amino-proline-derived cell penetrating peptide-superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents

Abstract

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