Aniline-catalyzed oxime chemistry was employed to conjugate a γ-amino-proline-derived cell penetrating peptide to superparamagnetic iron oxide nanoparticles (SPIONs). Internalization of the novel nanoconjugate into HeLa cells was found to be remarkably higher compared to the analogous TAT-SPION conjugate. © 2012 The Royal Society of Chemistry.
|Publication status||Published - 28 May 2012|
Cavalli, S., Carbajo, D., Acosta, M., Lope-Piedrafita, S., Candiota, A. P., Arús, C., Royo, M., & Albericio, F. (2012). Efficient γ-amino-proline-derived cell penetrating peptide-superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents. Chemical Communications, 48, 5322-5324. https://doi.org/10.1039/c2cc17937g