Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis

Joan Gavaldà, María Teresa Martín, Pedro López, Xavier Gomis, José Luís Ramírez, Dolors Rodríguez, Oscar Len, Yolanda Puigfel, Isabel Ruíz, Albert Pahissa

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Abstract

The efficacy of therapeutic aerosolized amphotericin B (AMB) was studied in a steroid-immunosuppressed murine model of invasive pulmonary aspergillosis. Nebulized liposomal AMB can be a valid approach to the treatment of this infection, with subjects showing significantly improved survival relative to that of subjects given intravenous deoxycholate AMB, as well as lower lung weights and pulmonary glucosamine levels. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)3028-3030
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number7
DOIs
Publication statusPublished - 1 Jul 2005

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    Gavaldà, J., Martín, M. T., López, P., Gomis, X., Ramírez, J. L., Rodríguez, D., Len, O., Puigfel, Y., Ruíz, I., & Pahissa, A. (2005). Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis. Antimicrobial Agents and Chemotherapy, 49(7), 3028-3030. https://doi.org/10.1128/AAC.49.7.3028-3030.2005