Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis

Joan Gavaldà; María Teresa Martín; Pedro López; Xavier Gomis; José Luís Ramírez; Dolors Rodríguez; Oscar Len; Yolanda Puigfel; Isabel Ruíz; Albert Pahissa

doi:10.1128/AAC.49.7.3028-3030.2005

Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis

Joan Gavaldà, María Teresa Martín, Pedro López, Xavier Gomis, José Luís Ramírez, Dolors Rodríguez, Oscar Len, Yolanda Puigfel, Isabel Ruíz, Albert Pahissa

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

52 Citations (Scopus)

Abstract

The efficacy of therapeutic aerosolized amphotericin B (AMB) was studied in a steroid-immunosuppressed murine model of invasive pulmonary aspergillosis. Nebulized liposomal AMB can be a valid approach to the treatment of this infection, with subjects showing significantly improved survival relative to that of subjects given intravenous deoxycholate AMB, as well as lower lung weights and pulmonary glucosamine levels. Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Original language	English
Pages (from-to)	3028-3030
Journal	Antimicrobial Agents and Chemotherapy
Volume	49
Issue number	7
DOIs	https://doi.org/10.1128/AAC.49.7.3028-3030.2005
Publication status	Published - 1 Jul 2005

Access to Document

10.1128/AAC.49.7.3028-3030.2005

Cite this

@article{819363e16c504cb7a5d5ad1be6da306b,

title = "Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis",

abstract = "The efficacy of therapeutic aerosolized amphotericin B (AMB) was studied in a steroid-immunosuppressed murine model of invasive pulmonary aspergillosis. Nebulized liposomal AMB can be a valid approach to the treatment of this infection, with subjects showing significantly improved survival relative to that of subjects given intravenous deoxycholate AMB, as well as lower lung weights and pulmonary glucosamine levels. Copyright {\textcopyright} 2005, American Society for Microbiology. All Rights Reserved.",

author = "Joan Gavald{\`a} and Mart{\'i}n, {Mar{\'i}a Teresa} and Pedro L{\'o}pez and Xavier Gomis and Ram{\'i}rez, {Jos{\'e} Lu{\'i}s} and Dolors Rodr{\'i}guez and Oscar Len and Yolanda Puigfel and Isabel Ru{\'i}z and Albert Pahissa",

year = "2005",

month = jul,

day = "1",

doi = "10.1128/AAC.49.7.3028-3030.2005",

language = "English",

volume = "49",

pages = "3028--3030",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "7",

}

TY - JOUR

T1 - Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis

AU - Gavaldà, Joan

AU - Martín, María Teresa

AU - López, Pedro

AU - Gomis, Xavier

AU - Ramírez, José Luís

AU - Rodríguez, Dolors

AU - Len, Oscar

AU - Puigfel, Yolanda

AU - Ruíz, Isabel

AU - Pahissa, Albert

PY - 2005/7/1

Y1 - 2005/7/1

N2 - The efficacy of therapeutic aerosolized amphotericin B (AMB) was studied in a steroid-immunosuppressed murine model of invasive pulmonary aspergillosis. Nebulized liposomal AMB can be a valid approach to the treatment of this infection, with subjects showing significantly improved survival relative to that of subjects given intravenous deoxycholate AMB, as well as lower lung weights and pulmonary glucosamine levels. Copyright © 2005, American Society for Microbiology. All Rights Reserved.

AB - The efficacy of therapeutic aerosolized amphotericin B (AMB) was studied in a steroid-immunosuppressed murine model of invasive pulmonary aspergillosis. Nebulized liposomal AMB can be a valid approach to the treatment of this infection, with subjects showing significantly improved survival relative to that of subjects given intravenous deoxycholate AMB, as well as lower lung weights and pulmonary glucosamine levels. Copyright © 2005, American Society for Microbiology. All Rights Reserved.

U2 - 10.1128/AAC.49.7.3028-3030.2005

DO - 10.1128/AAC.49.7.3028-3030.2005

M3 - Article

SN - 0066-4804

VL - 49

SP - 3028

EP - 3030

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 7

ER -

Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis

Abstract

Access to Document

Fingerprint

Cite this