Efficacy of methadone versus methadone and guanfacine in the detoxification of heroin-addicted patients

Luis San, Teresa Fernandez, Jordi Cami, Michael Gossop

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    14 Citations (Scopus)

    Abstract

    In a randomized double-blind study, the clinical efficacy of methadone vs. methadone and guanfacine was assessed in terms of evolution of opioid withdrawal symptoms during inpatient detoxification. A total of 144 patients were included and randomly allocated to three different treatment groups: methadone alone, and two combined treatment schedules (methadone plus 3 or 4 mg of guanfacine). No differences were observed among the three groups with regard to retention rate throughout the study period. Both therapies, methadone and methadone plus guanfacine, determined a slight increase in withdrawal scores when methadone was discontinued. However, guanfacine was unable to effectively control methadone-associated withdrawal symptoms. These results indicate that guanfacine does not effectively reduce the opioid withdrawal symptoms. © 1994.
    Original languageEnglish
    Pages (from-to)463-469
    JournalJournal of Substance Abuse Treatment
    Volume11
    Issue number5
    DOIs
    Publication statusPublished - 1 Jan 1994

    Keywords

    • guanfacine
    • heroin addiction
    • methadone
    • opiate withdrawal
    • treatment-efficacy

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