Efficacy of albendazole against Taenia multiceps larvae in experimentally infected goats

Sónia M.S. Afonso, Luis Neves, Alberto Pondja, Cristiano Macuamule, Samson Mukaratirwa, Margarita Arboix, Carles Cristòfol, Bettencourt P.S. Capece

Research output: Contribution to journalArticleResearchpeer-review

Abstract

© 2014 Elsevier B.V. A controlled trial was conducted to evaluate the efficacy of three therapeutics regimes of albendazole (ABZ) against Taenia multiceps larvae in experimental infected goats. Forty-nine goats experimentally infected with 3000 T. multiceps eggs were selected and randomly divided into treatment or control groups. Treatment with 10. mg/kg for 3 days for group 1 (G1), 10. mg/kg for group 2 (G2) and 20. mg/kg/day for group 3 (G3) was applied 2 months after infection; group 4 (G4) served as a control group. A treatment with doses of 10. mg/kg/day for 3 days on group 5 (G5) and group 6 (G6) was used as control, 5 months after the infection. The efficacy of ABZ was assessed as percentage of non-viable cysts which were determined by morphologic characteristics, movement and methyl blue staining technique. The efficacy of ABZ against 2 months old cysts was significantly different from the control and were 90.3% (28/31), 72.7% (8/11) and 73.9% (14/19) for G1, G2 and G3, respectively. No differences were observed in cyst viability between treated and control groups for 5-month old cysts. The results in this study indicate that ABZ is effective in goats against 2-month-old cysts of T. multiceps larva located in tissues outside the brain.
Original languageEnglish
Pages (from-to)304-307
JournalVeterinary Parasitology
Volume206
Issue number3-4
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Albendazole
  • Efficacy
  • Experimental infection
  • Goats
  • Taenia multiceps

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    Afonso, S. M. S., Neves, L., Pondja, A., Macuamule, C., Mukaratirwa, S., Arboix, M., Cristòfol, C., & Capece, B. P. S. (2014). Efficacy of albendazole against Taenia multiceps larvae in experimentally infected goats. Veterinary Parasitology, 206(3-4), 304-307. https://doi.org/10.1016/j.vetpar.2014.09.020