Efficacy of AdiDetox™ in reducing the toxicity of fumonisin B<inf>1</inf> in rats

Muzaffer Denli; Juan C. Blandon; Silvia Salado; Maria E. Guynot; Josefina Casas; Jose F. Pérez

doi:10.1016/j.fct.2015.01.024

Efficacy of AdiDetox™ in reducing the toxicity of fumonisin B<inf>1</inf> in rats

Muzaffer Denli, Juan C. Blandon, Silvia Salado, Maria E. Guynot, Josefina Casas, Jose F. Pérez

Department of Animal and Food Science

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

© 2015 Elsevier Ltd. The objective of this study is to evaluate the efficacy of a new mycotoxin inactivator (AdiDetox™) in reducing the toxic effects of fumonisin B1 (FB1) in the diet of rats. Sixty-four male Sprague-Dawley growing rats (125 g ± 1 g BW) were assigned to eight dietary treatments for seven days. The experiment had a 2 × 4 factorial arrangement with two levels of FB1 (0 mg and 15 mg of FB1/kg feed) and four levels of AdiDetox™ (0 g, 1 g, 2 g and 5 g /kg feed) in the diet. No significant differences were observed in the growth performance among treatments (P > 0.05), though low levels of sphingosine (So) and sphinganine (Sa) were detected in the liver. However, So and Sa and the Sa/So ratio in kidneys were higher in rats receiving the FB1 diets (P < 0.0001) than in those fed the Control diet. Supplementation of AdiDetox™ to the diet significantly reduced the toxic effects of FB1, leading to a significant decrease in the Sa content and in the Sa/So ratio in kidneys. In conclusion, the results suggest that AdiDetox™ can effectively reduce toxicity of FB1 in growing rats.

Original language	English
Pages (from-to)	60-63
Journal	Food and Chemical Toxicology
Volume	78
DOIs	https://doi.org/10.1016/j.fct.2015.01.024
Publication status	Published - 1 Apr 2015

Keywords

Adsorbent
Fumonisin B 1
Toxicity and rats

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@article{a448161c99044c808c34bd029e8d149e,

title = "Efficacy of AdiDetox{\texttrademark} in reducing the toxicity of fumonisin B1 in rats",

abstract = "{\textcopyright} 2015 Elsevier Ltd. The objective of this study is to evaluate the efficacy of a new mycotoxin inactivator (AdiDetox{\texttrademark}) in reducing the toxic effects of fumonisin B1 (FB1) in the diet of rats. Sixty-four male Sprague-Dawley growing rats (125 g ± 1 g BW) were assigned to eight dietary treatments for seven days. The experiment had a 2 × 4 factorial arrangement with two levels of FB1 (0 mg and 15 mg of FB1/kg feed) and four levels of AdiDetox{\texttrademark} (0 g, 1 g, 2 g and 5 g /kg feed) in the diet. No significant differences were observed in the growth performance among treatments (P > 0.05), though low levels of sphingosine (So) and sphinganine (Sa) were detected in the liver. However, So and Sa and the Sa/So ratio in kidneys were higher in rats receiving the FB1 diets (P < 0.0001) than in those fed the Control diet. Supplementation of AdiDetox{\texttrademark} to the diet significantly reduced the toxic effects of FB1, leading to a significant decrease in the Sa content and in the Sa/So ratio in kidneys. In conclusion, the results suggest that AdiDetox{\texttrademark} can effectively reduce toxicity of FB1 in growing rats.",

keywords = "Adsorbent, Fumonisin B 1, Toxicity and rats",

author = "Muzaffer Denli and Blandon, {Juan C.} and Silvia Salado and Guynot, {Maria E.} and Josefina Casas and P{\'e}rez, {Jose F.}",

year = "2015",

month = apr,

day = "1",

doi = "10.1016/j.fct.2015.01.024",

language = "English",

volume = "78",

pages = "60--63",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Efficacy of AdiDetox™ in reducing the toxicity of fumonisin B1 in rats

AU - Denli, Muzaffer

AU - Blandon, Juan C.

AU - Salado, Silvia

AU - Guynot, Maria E.

AU - Casas, Josefina

AU - Pérez, Jose F.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - © 2015 Elsevier Ltd. The objective of this study is to evaluate the efficacy of a new mycotoxin inactivator (AdiDetox™) in reducing the toxic effects of fumonisin B1 (FB1) in the diet of rats. Sixty-four male Sprague-Dawley growing rats (125 g ± 1 g BW) were assigned to eight dietary treatments for seven days. The experiment had a 2 × 4 factorial arrangement with two levels of FB1 (0 mg and 15 mg of FB1/kg feed) and four levels of AdiDetox™ (0 g, 1 g, 2 g and 5 g /kg feed) in the diet. No significant differences were observed in the growth performance among treatments (P > 0.05), though low levels of sphingosine (So) and sphinganine (Sa) were detected in the liver. However, So and Sa and the Sa/So ratio in kidneys were higher in rats receiving the FB1 diets (P < 0.0001) than in those fed the Control diet. Supplementation of AdiDetox™ to the diet significantly reduced the toxic effects of FB1, leading to a significant decrease in the Sa content and in the Sa/So ratio in kidneys. In conclusion, the results suggest that AdiDetox™ can effectively reduce toxicity of FB1 in growing rats.

AB - © 2015 Elsevier Ltd. The objective of this study is to evaluate the efficacy of a new mycotoxin inactivator (AdiDetox™) in reducing the toxic effects of fumonisin B1 (FB1) in the diet of rats. Sixty-four male Sprague-Dawley growing rats (125 g ± 1 g BW) were assigned to eight dietary treatments for seven days. The experiment had a 2 × 4 factorial arrangement with two levels of FB1 (0 mg and 15 mg of FB1/kg feed) and four levels of AdiDetox™ (0 g, 1 g, 2 g and 5 g /kg feed) in the diet. No significant differences were observed in the growth performance among treatments (P > 0.05), though low levels of sphingosine (So) and sphinganine (Sa) were detected in the liver. However, So and Sa and the Sa/So ratio in kidneys were higher in rats receiving the FB1 diets (P < 0.0001) than in those fed the Control diet. Supplementation of AdiDetox™ to the diet significantly reduced the toxic effects of FB1, leading to a significant decrease in the Sa content and in the Sa/So ratio in kidneys. In conclusion, the results suggest that AdiDetox™ can effectively reduce toxicity of FB1 in growing rats.

KW - Adsorbent

KW - Fumonisin B 1

KW - Toxicity and rats

U2 - 10.1016/j.fct.2015.01.024

DO - 10.1016/j.fct.2015.01.024

M3 - Article

VL - 78

SP - 60

EP - 63

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

ER -