Efficacy of AdiDetox™ in reducing the toxicity of fumonisin B<inf>1</inf> in rats

Muzaffer Denli, Juan C. Blandon, Silvia Salado, Maria E. Guynot, Josefina Casas, Jose F. Pérez

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

© 2015 Elsevier Ltd. The objective of this study is to evaluate the efficacy of a new mycotoxin inactivator (AdiDetox™) in reducing the toxic effects of fumonisin B1 (FB1) in the diet of rats. Sixty-four male Sprague-Dawley growing rats (125 g ± 1 g BW) were assigned to eight dietary treatments for seven days. The experiment had a 2 × 4 factorial arrangement with two levels of FB1 (0 mg and 15 mg of FB1/kg feed) and four levels of AdiDetox™ (0 g, 1 g, 2 g and 5 g /kg feed) in the diet. No significant differences were observed in the growth performance among treatments (P > 0.05), though low levels of sphingosine (So) and sphinganine (Sa) were detected in the liver. However, So and Sa and the Sa/So ratio in kidneys were higher in rats receiving the FB1 diets (P < 0.0001) than in those fed the Control diet. Supplementation of AdiDetox™ to the diet significantly reduced the toxic effects of FB1, leading to a significant decrease in the Sa content and in the Sa/So ratio in kidneys. In conclusion, the results suggest that AdiDetox™ can effectively reduce toxicity of FB1 in growing rats.
Original languageEnglish
Pages (from-to)60-63
JournalFood and Chemical Toxicology
Volume78
DOIs
Publication statusPublished - 1 Apr 2015

Keywords

  • Adsorbent
  • Fumonisin B 1
  • Toxicity and rats

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