Effects of sub-chronic combined treatment with pergolide and caffeine on contralateral rotational behavior in unilateral 6-hydroxydopamine-denervated rats

Gemma Prat, Patricia Robledo, Antonia Rubio, Manel Barbanoj, Francesc Janeé, Miquel Casas

    Research output: Contribution to journalArticleResearchpeer-review

    8 Citations (Scopus)

    Abstract

    We studied the synergistic effects of pergolide and bromocriptine with caffeine on turning behavior in 6-OHDA denervated rats. Both pergolide and bromocriptine were synergistic with caffeine, and prevented tolerance to caffeine-induced turning. When caffeine was removed, tolerance to bromocriptine effects was observed for 1 day only, while no tolerance was observed to pergolide. These results suggest that caffeine could be useful in the treatment of Parkinson's disease, preferentially as an adjuvant of mixed dopaminergic agonists like pergolide.© 2000 Elsevier Science B.V.
    Original languageEnglish
    Pages (from-to)376-379
    JournalBrain Research
    Volume868
    DOIs
    Publication statusPublished - 23 Jun 2000

    Keywords

    • 6-Hydroxydopamine lesions
    • Dopamine agonists
    • Levodopa treatment
    • Parkinson's disease

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