We studied the synergistic effects of pergolide and bromocriptine with caffeine on turning behavior in 6-OHDA denervated rats. Both pergolide and bromocriptine were synergistic with caffeine, and prevented tolerance to caffeine-induced turning. When caffeine was removed, tolerance to bromocriptine effects was observed for 1 day only, while no tolerance was observed to pergolide. These results suggest that caffeine could be useful in the treatment of Parkinson's disease, preferentially as an adjuvant of mixed dopaminergic agonists like pergolide.© 2000 Elsevier Science B.V.
|Publication status||Published - 23 Jun 2000|
- 6-Hydroxydopamine lesions
- Dopamine agonists
- Levodopa treatment
- Parkinson's disease