Utilizing psychogenetically selected Roman high- and low-avoidance rats (RHA/Verh and RLA/Verh), the present experiments investigated the effects of prenatally administered vehicle and diazepam (1 and 3 mg/kg per day, SC) on the behavior and neurochemistry of adult, male offspring. Active, two-way avoidance behavior was analyzed in 96 rats, at 6 months of age, and swimming navigation in 68 others, at 11 months. Three weeks after testing, selected brain areas from the latter animals were immunoassayed for benzodiazepine (BZD)-like molecules. The 3 mg/kg dose of diazepam both decreased freezing behavior in the shuttle box and reduced the hippocampal content of BZD-like molecules in the RLA/Verh male rats. Swimming navigation (spatial learning), at which the RLA/Verh rats were more adept, was not specifically affected by prenatal diazepam in either rat line. The possibility exists that an increased hippocampal release of BZD-like substances may be necessary to alter shuttle box behavior in RLA/Verh rats. © 1995 Springer-Verlag.
- Benzodiazepine-like molecules
- Genetic selection
- Roman high- and low-avoidance rats
- Swimming navigation
- Two-way, active avoidance
Driscoll, P., Ferré, P., Fernández-Teruel, A., Tobeña, A., Escorihuela, R. M., Levi de Stein, M., Wolfman, C., & Medina, J. (1995). Effects of prenatal diazepam on two-way avoidance behavior, swimming navigation and brain levels of benzodiazepine-like molecules in male roman high- and low-avoidance rats. Psychopharmacology, 122, 51-57. https://doi.org/10.1007/BF02246441