Effects of Posttraining Damage to the Pedunculopontine Tegmental Nucleus on Conditioned Stimulus Transfer in Two-Way Active Avoidance in Rats

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Abstract

The effects of posttraining excitotoxic lesions of the pedunculopontine tegmental nucleus (PPTg) on two-way active avoidance after changing the conditioned stimulus (CS) used during prelesion training were examined. Prelesion training was carried out with either a tone or a light as the CS, and this CS was changed during postlesion training. Replacing the tone with a light reduced the performance of control and lesioned rats, but the degree of reduction was higher in the latter. Replacing the light with a tone had slight detrimental effects in lesioned rats but not in controls. Thus, posttraining PPTg lesions slowed down the reacquisition of shuttle-box avoidance under conditions of CS transfer, an effect that may be attributable to disruption of attention and/or gating of sensory stimuli. © 2007 American Psychological Association.
Original languageEnglish
Pages (from-to)411-421
JournalBehavioral Neuroscience
Volume121
Issue number2
DOIs
Publication statusPublished - 1 Apr 2007

Keywords

  • conditioned stimulus modality
  • conditioned stimulus transfer
  • pedunculopontine tegmental nucleus
  • two-way active avoidance

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