Effects of platelet-rich plasma on intestinal wound healing in pigs

Laura Fresno; Dolors Fondevila; Otilia Bambo; Asiul Chacaltana; Félix García; Anna Andaluz

doi:10.1016/j.tvjl.2009.06.009

Effects of platelet-rich plasma on intestinal wound healing in pigs

Laura Fresno, Dolors Fondevila, Otilia Bambo, Asiul Chacaltana, Félix García, Anna Andaluz

Research output: Contribution to journal › Article › Research › peer-review

46 Citations (Scopus)

Abstract

Anastomotic dehiscence and leakage remain a major problem in gastrointestinal surgery. Recently, attention has been focused on cellular acceleration of the wound healing process using platelet-rich plasma (PRP) and this study reports the effects of PRP on intestinal wound healing in pigs. Autologous PRP was obtained from 35 pigs that were then subjected to two intestinal anastomosis procedures. Activated PRP was applied at one of the anastomosis sites, while the other site served as control. After 24, 48, 72 and 96. h and then at 7. days, histology was performed and wound breaking strength was measured at 72. h and 7. days. PRP application appeared to increase granulation tissue and fibrosis, but did not influence anastomotic breaking strength. © 2009 Elsevier Ltd.

Original language	English
Pages (from-to)	322-327
Journal	Veterinary Journal
Volume	185
DOIs	https://doi.org/10.1016/j.tvjl.2009.06.009
Publication status	Published - 1 Jan 2010

Keywords

Breaking strength
Intestine
Pig
Platelet-rich plasma
Wound healing

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10.1016/j.tvjl.2009.06.009

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title = "Effects of platelet-rich plasma on intestinal wound healing in pigs",

abstract = "Anastomotic dehiscence and leakage remain a major problem in gastrointestinal surgery. Recently, attention has been focused on cellular acceleration of the wound healing process using platelet-rich plasma (PRP) and this study reports the effects of PRP on intestinal wound healing in pigs. Autologous PRP was obtained from 35 pigs that were then subjected to two intestinal anastomosis procedures. Activated PRP was applied at one of the anastomosis sites, while the other site served as control. After 24, 48, 72 and 96. h and then at 7. days, histology was performed and wound breaking strength was measured at 72. h and 7. days. PRP application appeared to increase granulation tissue and fibrosis, but did not influence anastomotic breaking strength. {\textcopyright} 2009 Elsevier Ltd.",

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T1 - Effects of platelet-rich plasma on intestinal wound healing in pigs

AU - Fresno, Laura

AU - Fondevila, Dolors

AU - Bambo, Otilia

AU - Chacaltana, Asiul

AU - García, Félix

AU - Andaluz, Anna

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Anastomotic dehiscence and leakage remain a major problem in gastrointestinal surgery. Recently, attention has been focused on cellular acceleration of the wound healing process using platelet-rich plasma (PRP) and this study reports the effects of PRP on intestinal wound healing in pigs. Autologous PRP was obtained from 35 pigs that were then subjected to two intestinal anastomosis procedures. Activated PRP was applied at one of the anastomosis sites, while the other site served as control. After 24, 48, 72 and 96. h and then at 7. days, histology was performed and wound breaking strength was measured at 72. h and 7. days. PRP application appeared to increase granulation tissue and fibrosis, but did not influence anastomotic breaking strength. © 2009 Elsevier Ltd.

AB - Anastomotic dehiscence and leakage remain a major problem in gastrointestinal surgery. Recently, attention has been focused on cellular acceleration of the wound healing process using platelet-rich plasma (PRP) and this study reports the effects of PRP on intestinal wound healing in pigs. Autologous PRP was obtained from 35 pigs that were then subjected to two intestinal anastomosis procedures. Activated PRP was applied at one of the anastomosis sites, while the other site served as control. After 24, 48, 72 and 96. h and then at 7. days, histology was performed and wound breaking strength was measured at 72. h and 7. days. PRP application appeared to increase granulation tissue and fibrosis, but did not influence anastomotic breaking strength. © 2009 Elsevier Ltd.

KW - Breaking strength

KW - Intestine

KW - Pig

KW - Platelet-rich plasma

KW - Wound healing

U2 - 10.1016/j.tvjl.2009.06.009

DO - 10.1016/j.tvjl.2009.06.009

M3 - Article

SN - 1090-0233

VL - 185

SP - 322

EP - 327

JO - Veterinary Journal

JF - Veterinary Journal

ER -

Effects of platelet-rich plasma on intestinal wound healing in pigs

Abstract

Keywords

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