Effects of platelet-rich plasma on intestinal wound healing in pigs

Laura Fresno, Dolors Fondevila, Otilia Bambo, Asiul Chacaltana, Félix García, Anna Andaluz

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)


Anastomotic dehiscence and leakage remain a major problem in gastrointestinal surgery. Recently, attention has been focused on cellular acceleration of the wound healing process using platelet-rich plasma (PRP) and this study reports the effects of PRP on intestinal wound healing in pigs. Autologous PRP was obtained from 35 pigs that were then subjected to two intestinal anastomosis procedures. Activated PRP was applied at one of the anastomosis sites, while the other site served as control. After 24, 48, 72 and 96. h and then at 7. days, histology was performed and wound breaking strength was measured at 72. h and 7. days. PRP application appeared to increase granulation tissue and fibrosis, but did not influence anastomotic breaking strength. © 2009 Elsevier Ltd.
Original languageEnglish
Pages (from-to)322-327
JournalVeterinary Journal
Publication statusPublished - 1 Jan 2010


  • Breaking strength
  • Intestine
  • Pig
  • Platelet-rich plasma
  • Wound healing


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