Abstract

Anastomotic dehiscence and leakage remain a major problem in gastrointestinal surgery. Recently, attention has been focused on cellular acceleration of the wound healing process using platelet-rich plasma (PRP) and this study reports the effects of PRP on intestinal wound healing in pigs. Autologous PRP was obtained from 35 pigs that were then subjected to two intestinal anastomosis procedures. Activated PRP was applied at one of the anastomosis sites, while the other site served as control. After 24, 48, 72 and 96. h and then at 7. days, histology was performed and wound breaking strength was measured at 72. h and 7. days. PRP application appeared to increase granulation tissue and fibrosis, but did not influence anastomotic breaking strength. © 2009 Elsevier Ltd.
Original languageEnglish
Pages (from-to)322-327
JournalVeterinary Journal
Volume185
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • Breaking strength
  • Intestine
  • Pig
  • Platelet-rich plasma
  • Wound healing

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