Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs

Santiago Cerrato, Pilar Brazis, Maria Federica della Valle, Alda Miolo, Stefania Petrosino, Vincenzo Di Marzo, Anna Puigdemont

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26 Citations (Scopus)

Abstract

Palmitoylethanolamide (PEA) is an endogenous lipid mediator with anti-inflammatory and anti-hyperalgesic properties. The main objective of the present study was to evaluate the effects of PEA on the cutaneous allergic inflammatory reaction induced by different immunological and non-immunological stimuli in hypersensitive dogs. Six spontaneously Ascaris hypersensitive Beagle dogs were challenged with intradermal injections of Ascaris suum extract, substance P and anti-canine IgE, before and after a single oral administration of PEA at doses of 3, 10 and 30 mg/kg. A significant reduction in wheal area induced by both antigen and anti-canine IgE challenge was observed after PEA administration. No significant differences were observed between the two higher doses studied, suggesting that the 10 mg/kg dose had exerted the maximum inhibitory effect. When blood levels of PEA were compared with the effects at different times, an evident correlation was obtained. However, the anti-inflammatory effects of PEA were more long-lasting than their plasma concentrations. The intradermal injection of substance P did not reveal any skin reaction (wheal or erythema formation) at any of the concentrations tested. In conclusion, PEA might constitute a new therapeutic strategy for the treatment of allergic inflammatory skin diseases in companion animals. © 2011 Elsevier Ltd.
Original languageEnglish
Pages (from-to)377-382
JournalVeterinary Journal
Volume191
Issue number3
DOIs
Publication statusPublished - 1 Mar 2012

Keywords

  • Ascaris suum
  • Canine
  • Hypersensitivity
  • IgE
  • Palmitoylethanolamide

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