Effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus: European Paediatric Hepatitis C Virus Network

P. A. Tovo; M. L. Newell; O. Coll; B. Martinez de Tejada; M. Lanari; I. Bosi; I. Papa; A. Zanetti; J. Ruiz Contreras; A. Manzanares; J. T. Ramos; A. Vegnente; R. Iorio; C. Fabris; A. M. Bandelloni; C. Tibaldi; L. M. Ciria; E. Palomba; C. Riva; C. Scolfaro; W. Buffolano; I. Scotese; A. Micco; M. Marcellini; M. R. Sartorelli; S. Mattia; A. B. Bohlin; B. Fischler; S. Lindgren; G. Lindh; A. Maccabruni; I. Pacati; L. Arlandi; S. Polywka; K. Butler; A. De Maria; D. Bassetti; F. Fioredda; S. Boni; C. Gotta; A. Mazza; I. Grosch-Wörner; C. Feiterna Sperling; I. Quinti; G. Scaravelli; P. Cigna; G. Cilla; J. Echeverria; H. Souayah; D. Grossman; J. Levy; G. Bona; J. Y.Q. Mok; P. Martin Fontelos; J. Villota Arrieta; F. Asensi-Botet; M. C. Otero; D. Pérez-Tamarit; G. Zuin; B. Saccani; G. V. Zuccotti; E. Riva; A. Gamboni; R. Wejstal; G. Norkrans; H. Scherpbier; A. Mûr; M. Viñolas; A. Ruiz Extremera; L. Cabero Roura; J. McBertran Sanges; J. A. McLeon Leal; A. Rodriguez; A. Sarrión-Auñón; A. Corrias; C. Boucher; A. Hatzakis; P. Grella

doi:10.1016/S0306-5456(00)00088-7

Effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus: European Paediatric Hepatitis C Virus Network

P. A. Tovo, M. L. Newell, O. Coll, B. Martinez de Tejada, M. Lanari, I. Bosi, I. Papa, A. Zanetti, J. Ruiz Contreras, A. Manzanares, J. T. Ramos, A. Vegnente, R. Iorio, C. Fabris, A. M. Bandelloni, C. Tibaldi, L. M. Ciria, E. Palomba, C. Riva, C. ScolfaroW. Buffolano, I. Scotese, A. Micco, M. Marcellini, M. R. Sartorelli, S. Mattia, A. B. Bohlin, B. Fischler, S. Lindgren, G. Lindh, A. Maccabruni, I. Pacati, L. Arlandi, S. Polywka, K. Butler, A. De Maria, D. Bassetti, F. Fioredda, S. Boni, C. Gotta, A. Mazza, I. Grosch-Wörner, C. Feiterna Sperling, I. Quinti, G. Scaravelli, P. Cigna, G. Cilla, J. Echeverria, H. Souayah, D. Grossman, J. Levy, G. Bona, J. Y.Q. Mok, P. Martin Fontelos, J. Villota Arrieta, F. Asensi-Botet, M. C. Otero, D. Pérez-Tamarit, G. Zuin, B. Saccani, G. V. Zuccotti, E. Riva, A. Gamboni, R. Wejstal, G. Norkrans, H. Scherpbier, A. Mûr, M. Viñolas, A. Ruiz Extremera, L. Cabero Roura, J. McBertran Sanges, J. A. McLeon Leal, A. Rodriguez, A. Sarrión-Auñón, A. Corrias, C. Boucher, A. Hatzakis, P. Grella

Department of Paediatrics, Obstetrics and Gynaecology and Preventive Medicine and Public Health

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Abstract

Objective: To investigate the effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus. Design: Pooled retrospective analysis of prospectively collected data. Sample: Data on hepatitis C virus seropositive mothers and their children identified around delivery were sent from 24 centres of the European Paediatric Hepatitis C Virus Network. Main outcome measures: Hepatitis C virus infection status of children born to hepatitis C virus infected women. Results: A total of 1,474 hepatitis C virus infected women were identified, of whom 503 (35%) were co-infected with HIV. Co-infected women were more than twice as likely to transmit hepatitis C virus to their children than women with hepatitis C virus infection alone. Overall 9.2% (136/1474) of children were hepatitis C virus infected. Among the women with hepatitis C virus infection-only, multivariate analyses did not show a significant effect of mode of delivery and breastfeeding: caesarean section vs vaginal delivery OR = 1.17, P: 0.66; breastfed versus non-breastfed OR = 1.07, P = 0.83. However, HIV co-infected women delivered by caesarean section were 60% less likely to have an infected child than those delivered vaginally (OR = 0.36, P = 0.01) and those who breastfed were about four times more likely to infect their children than those who did not (OR = 6.41, P: 0.03). HIV infected children were three to four times more likely also to be hepatitis C virus infected than children without HIV infection (crude OR = 3.76, 95% CI 1.89-7.41). Conclusions: These results do not support a recommendation of elective caesarean section or avoidance of breastfeeding for women with hepatitis C virus infection only, but the case for HIV infected women undergoing caesarean section delivery and avoiding breastfeeding is strengthened if they are also hepatitis C virus infected.

Original language	English
Pages (from-to)	371-377
Journal	British Journal of Obstetrics and Gynaecology
Volume	108
Issue number	4
DOIs	https://doi.org/10.1016/S0306-5456(00)00088-7
Publication status	Published - 1 Jan 2001

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10.1016/S0306-5456(00)00088-7

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Tovo, P. A., Newell, M. L., Coll, O., de Tejada, B. M., Lanari, M., Bosi, I., Papa, I., Zanetti, A., Contreras, J. R., Manzanares, A., Ramos, J. T., Vegnente, A., Iorio, R., Fabris, C., Bandelloni, A. M., Tibaldi, C., Ciria, L. M., Palomba, E., Riva, C., ... Grella, P. (2001). Effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus: European Paediatric Hepatitis C Virus Network. British Journal of Obstetrics and Gynaecology, 108(4), 371-377. https://doi.org/10.1016/S0306-5456(00)00088-7

@article{0719b32bd70148de9fb73e795bb070a5,

title = "Effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus: European Paediatric Hepatitis C Virus Network",

abstract = "Objective: To investigate the effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus. Design: Pooled retrospective analysis of prospectively collected data. Sample: Data on hepatitis C virus seropositive mothers and their children identified around delivery were sent from 24 centres of the European Paediatric Hepatitis C Virus Network. Main outcome measures: Hepatitis C virus infection status of children born to hepatitis C virus infected women. Results: A total of 1,474 hepatitis C virus infected women were identified, of whom 503 (35%) were co-infected with HIV. Co-infected women were more than twice as likely to transmit hepatitis C virus to their children than women with hepatitis C virus infection alone. Overall 9.2% (136/1474) of children were hepatitis C virus infected. Among the women with hepatitis C virus infection-only, multivariate analyses did not show a significant effect of mode of delivery and breastfeeding: caesarean section vs vaginal delivery OR = 1.17, P: 0.66; breastfed versus non-breastfed OR = 1.07, P = 0.83. However, HIV co-infected women delivered by caesarean section were 60% less likely to have an infected child than those delivered vaginally (OR = 0.36, P = 0.01) and those who breastfed were about four times more likely to infect their children than those who did not (OR = 6.41, P: 0.03). HIV infected children were three to four times more likely also to be hepatitis C virus infected than children without HIV infection (crude OR = 3.76, 95% CI 1.89-7.41). Conclusions: These results do not support a recommendation of elective caesarean section or avoidance of breastfeeding for women with hepatitis C virus infection only, but the case for HIV infected women undergoing caesarean section delivery and avoiding breastfeeding is strengthened if they are also hepatitis C virus infected.",

author = "Tovo, {P. A.} and Newell, {M. L.} and O. Coll and {de Tejada}, {B. Martinez} and M. Lanari and I. Bosi and I. Papa and A. Zanetti and Contreras, {J. Ruiz} and A. Manzanares and Ramos, {J. T.} and A. Vegnente and R. Iorio and C. Fabris and Bandelloni, {A. M.} and C. Tibaldi and Ciria, {L. M.} and E. Palomba and C. Riva and C. Scolfaro and W. Buffolano and I. Scotese and A. Micco and M. Marcellini and Sartorelli, {M. R.} and S. Mattia and Bohlin, {A. B.} and B. Fischler and S. Lindgren and G. Lindh and A. Maccabruni and I. Pacati and L. Arlandi and S. Polywka and K. Butler and {De Maria}, A. and D. Bassetti and F. Fioredda and S. Boni and C. Gotta and A. Mazza and I. Grosch-W{\"o}rner and Sperling, {C. Feiterna} and I. Quinti and G. Scaravelli and P. Cigna and G. Cilla and J. Echeverria and H. Souayah and D. Grossman and J. Levy and G. Bona and Mok, {J. Y.Q.} and Fontelos, {P. Martin} and Arrieta, {J. Villota} and F. Asensi-Botet and Otero, {M. C.} and D. P{\'e}rez-Tamarit and G. Zuin and B. Saccani and Zuccotti, {G. V.} and E. Riva and A. Gamboni and R. Wejstal and G. Norkrans and H. Scherpbier and A. M{\^u}r and M. Vi{\~n}olas and Extremera, {A. Ruiz} and Roura, {L. Cabero} and {McBertran Sanges}, J. and {McLeon Leal}, {J. A.} and A. Rodriguez and A. Sarri{\'o}n-Au{\~n}{\'o}n and A. Corrias and C. Boucher and A. Hatzakis and P. Grella",

year = "2001",

month = jan,

day = "1",

doi = "10.1016/S0306-5456(00)00088-7",

language = "English",

volume = "108",

pages = "371--377",

number = "4",

}

Tovo, PA, Newell, ML, Coll, O, de Tejada, BM, Lanari, M, Bosi, I, Papa, I, Zanetti, A, Contreras, JR, Manzanares, A, Ramos, JT, Vegnente, A, Iorio, R, Fabris, C, Bandelloni, AM, Tibaldi, C, Ciria, LM, Palomba, E, Riva, C, Scolfaro, C, Buffolano, W, Scotese, I, Micco, A, Marcellini, M, Sartorelli, MR, Mattia, S, Bohlin, AB, Fischler, B, Lindgren, S, Lindh, G, Maccabruni, A, Pacati, I, Arlandi, L, Polywka, S, Butler, K, De Maria, A, Bassetti, D, Fioredda, F, Boni, S, Gotta, C, Mazza, A, Grosch-Wörner, I, Sperling, CF, Quinti, I, Scaravelli, G, Cigna, P, Cilla, G, Echeverria, J, Souayah, H, Grossman, D, Levy, J, Bona, G, Mok, JYQ, Fontelos, PM, Arrieta, JV, Asensi-Botet, F, Otero, MC, Pérez-Tamarit, D, Zuin, G, Saccani, B, Zuccotti, GV, Riva, E, Gamboni, A, Wejstal, R, Norkrans, G, Scherpbier, H, Mûr, A, Viñolas, M, Extremera, AR, Roura, LC, McBertran Sanges, J, McLeon Leal, JA, Rodriguez, A, Sarrión-Auñón, A, Corrias, A, Boucher, C, Hatzakis, A & Grella, P 2001, 'Effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus: European Paediatric Hepatitis C Virus Network', British Journal of Obstetrics and Gynaecology, vol. 108, no. 4, pp. 371-377. https://doi.org/10.1016/S0306-5456(00)00088-7

Effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus: European Paediatric Hepatitis C Virus Network. / Tovo, P. A.; Newell, M. L.; Coll, O. et al.

In: British Journal of Obstetrics and Gynaecology, Vol. 108, No. 4, 01.01.2001, p. 371-377.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus: European Paediatric Hepatitis C Virus Network

AU - Tovo, P. A.

AU - Newell, M. L.

AU - Coll, O.

AU - de Tejada, B. Martinez

AU - Lanari, M.

AU - Bosi, I.

AU - Papa, I.

AU - Zanetti, A.

AU - Contreras, J. Ruiz

AU - Manzanares, A.

AU - Ramos, J. T.

AU - Vegnente, A.

AU - Iorio, R.

AU - Fabris, C.

AU - Bandelloni, A. M.

AU - Tibaldi, C.

AU - Ciria, L. M.

AU - Palomba, E.

AU - Riva, C.

AU - Scolfaro, C.

AU - Buffolano, W.

AU - Scotese, I.

AU - Micco, A.

AU - Marcellini, M.

AU - Sartorelli, M. R.

AU - Mattia, S.

AU - Bohlin, A. B.

AU - Fischler, B.

AU - Lindgren, S.

AU - Lindh, G.

AU - Maccabruni, A.

AU - Pacati, I.

AU - Arlandi, L.

AU - Polywka, S.

AU - Butler, K.

AU - De Maria, A.

AU - Bassetti, D.

AU - Fioredda, F.

AU - Boni, S.

AU - Gotta, C.

AU - Mazza, A.

AU - Grosch-Wörner, I.

AU - Sperling, C. Feiterna

AU - Quinti, I.

AU - Scaravelli, G.

AU - Cigna, P.

AU - Cilla, G.

AU - Echeverria, J.

AU - Souayah, H.

AU - Grossman, D.

AU - Levy, J.

AU - Bona, G.

AU - Mok, J. Y.Q.

AU - Fontelos, P. Martin

AU - Arrieta, J. Villota

AU - Asensi-Botet, F.

AU - Otero, M. C.

AU - Pérez-Tamarit, D.

AU - Zuin, G.

AU - Saccani, B.

AU - Zuccotti, G. V.

AU - Riva, E.

AU - Gamboni, A.

AU - Wejstal, R.

AU - Norkrans, G.

AU - Scherpbier, H.

AU - Mûr, A.

AU - Viñolas, M.

AU - Extremera, A. Ruiz

AU - Roura, L. Cabero

AU - McBertran Sanges, J.

AU - McLeon Leal, J. A.

AU - Rodriguez, A.

AU - Sarrión-Auñón, A.

AU - Corrias, A.

AU - Boucher, C.

AU - Hatzakis, A.

AU - Grella, P.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Objective: To investigate the effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus. Design: Pooled retrospective analysis of prospectively collected data. Sample: Data on hepatitis C virus seropositive mothers and their children identified around delivery were sent from 24 centres of the European Paediatric Hepatitis C Virus Network. Main outcome measures: Hepatitis C virus infection status of children born to hepatitis C virus infected women. Results: A total of 1,474 hepatitis C virus infected women were identified, of whom 503 (35%) were co-infected with HIV. Co-infected women were more than twice as likely to transmit hepatitis C virus to their children than women with hepatitis C virus infection alone. Overall 9.2% (136/1474) of children were hepatitis C virus infected. Among the women with hepatitis C virus infection-only, multivariate analyses did not show a significant effect of mode of delivery and breastfeeding: caesarean section vs vaginal delivery OR = 1.17, P: 0.66; breastfed versus non-breastfed OR = 1.07, P = 0.83. However, HIV co-infected women delivered by caesarean section were 60% less likely to have an infected child than those delivered vaginally (OR = 0.36, P = 0.01) and those who breastfed were about four times more likely to infect their children than those who did not (OR = 6.41, P: 0.03). HIV infected children were three to four times more likely also to be hepatitis C virus infected than children without HIV infection (crude OR = 3.76, 95% CI 1.89-7.41). Conclusions: These results do not support a recommendation of elective caesarean section or avoidance of breastfeeding for women with hepatitis C virus infection only, but the case for HIV infected women undergoing caesarean section delivery and avoiding breastfeeding is strengthened if they are also hepatitis C virus infected.

AB - Objective: To investigate the effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus. Design: Pooled retrospective analysis of prospectively collected data. Sample: Data on hepatitis C virus seropositive mothers and their children identified around delivery were sent from 24 centres of the European Paediatric Hepatitis C Virus Network. Main outcome measures: Hepatitis C virus infection status of children born to hepatitis C virus infected women. Results: A total of 1,474 hepatitis C virus infected women were identified, of whom 503 (35%) were co-infected with HIV. Co-infected women were more than twice as likely to transmit hepatitis C virus to their children than women with hepatitis C virus infection alone. Overall 9.2% (136/1474) of children were hepatitis C virus infected. Among the women with hepatitis C virus infection-only, multivariate analyses did not show a significant effect of mode of delivery and breastfeeding: caesarean section vs vaginal delivery OR = 1.17, P: 0.66; breastfed versus non-breastfed OR = 1.07, P = 0.83. However, HIV co-infected women delivered by caesarean section were 60% less likely to have an infected child than those delivered vaginally (OR = 0.36, P = 0.01) and those who breastfed were about four times more likely to infect their children than those who did not (OR = 6.41, P: 0.03). HIV infected children were three to four times more likely also to be hepatitis C virus infected than children without HIV infection (crude OR = 3.76, 95% CI 1.89-7.41). Conclusions: These results do not support a recommendation of elective caesarean section or avoidance of breastfeeding for women with hepatitis C virus infection only, but the case for HIV infected women undergoing caesarean section delivery and avoiding breastfeeding is strengthened if they are also hepatitis C virus infected.

U2 - 10.1016/S0306-5456(00)00088-7

DO - 10.1016/S0306-5456(00)00088-7

M3 - Article

VL - 108

SP - 371

EP - 377

IS - 4

ER -

Effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus: European Paediatric Hepatitis C Virus Network

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