Effects of ionizing radiation on oocytes of prepubertally irradiated rats

I. Martinez-Flores; C. Saez; J. Egozcue; M. Garcia

Effects of ionizing radiation on oocytes of prepubertally irradiated rats

I. Martinez-Flores, C. Saez, J. Egozcue, M. Garcia

Department of Cellular Biology, Physiology and Immunology

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

Purpose: To characterize the effects of ionizing radiation on the immature oocytes of prepubertal rats aged 16-20 days old. Materials and methods: The abdomen of Sprague Dawley (SD) female rats was exposed to 0, 1 and 2 Gy of X-rays. The effects were analysed when the animals became adults (80 days old) using as parameters the number of implantation sites, embryonic loss, dominant lethality and the synaptonemal complex (SC) analysis of Fl female foetuses. Results: A statistically significant decrease in the fertility of the 2 Gy irradiated rats was observed. However, the SC analysis of Fl female foetuses showed no cytogenetic damage that could be attributed to radiation. Conclusions: A reproductive effect was demonstrated but no inherited genetic damage was detected by SC analysis in female foetuses of irradiated mothers.

Original language	English
Pages (from-to)	1403-1407
Journal	International Journal of Radiation Biology
Volume	76
Issue number	10
Publication status	Published - 1 Jan 2000

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title = "Effects of ionizing radiation on oocytes of prepubertally irradiated rats",

abstract = "Purpose: To characterize the effects of ionizing radiation on the immature oocytes of prepubertal rats aged 16-20 days old. Materials and methods: The abdomen of Sprague Dawley (SD) female rats was exposed to 0, 1 and 2 Gy of X-rays. The effects were analysed when the animals became adults (80 days old) using as parameters the number of implantation sites, embryonic loss, dominant lethality and the synaptonemal complex (SC) analysis of Fl female foetuses. Results: A statistically significant decrease in the fertility of the 2 Gy irradiated rats was observed. However, the SC analysis of Fl female foetuses showed no cytogenetic damage that could be attributed to radiation. Conclusions: A reproductive effect was demonstrated but no inherited genetic damage was detected by SC analysis in female foetuses of irradiated mothers.",

author = "I. Martinez-Flores and C. Saez and J. Egozcue and M. Garcia",

year = "2000",

month = jan,

day = "1",

language = "English",

volume = "76",

pages = "1403--1407",

journal = "International Journal of Radiation Biology",

issn = "0955-3002",

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number = "10",

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TY - JOUR

T1 - Effects of ionizing radiation on oocytes of prepubertally irradiated rats

AU - Martinez-Flores, I.

AU - Saez, C.

AU - Egozcue, J.

AU - Garcia, M.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Purpose: To characterize the effects of ionizing radiation on the immature oocytes of prepubertal rats aged 16-20 days old. Materials and methods: The abdomen of Sprague Dawley (SD) female rats was exposed to 0, 1 and 2 Gy of X-rays. The effects were analysed when the animals became adults (80 days old) using as parameters the number of implantation sites, embryonic loss, dominant lethality and the synaptonemal complex (SC) analysis of Fl female foetuses. Results: A statistically significant decrease in the fertility of the 2 Gy irradiated rats was observed. However, the SC analysis of Fl female foetuses showed no cytogenetic damage that could be attributed to radiation. Conclusions: A reproductive effect was demonstrated but no inherited genetic damage was detected by SC analysis in female foetuses of irradiated mothers.

AB - Purpose: To characterize the effects of ionizing radiation on the immature oocytes of prepubertal rats aged 16-20 days old. Materials and methods: The abdomen of Sprague Dawley (SD) female rats was exposed to 0, 1 and 2 Gy of X-rays. The effects were analysed when the animals became adults (80 days old) using as parameters the number of implantation sites, embryonic loss, dominant lethality and the synaptonemal complex (SC) analysis of Fl female foetuses. Results: A statistically significant decrease in the fertility of the 2 Gy irradiated rats was observed. However, the SC analysis of Fl female foetuses showed no cytogenetic damage that could be attributed to radiation. Conclusions: A reproductive effect was demonstrated but no inherited genetic damage was detected by SC analysis in female foetuses of irradiated mothers.

M3 - Article

VL - 76

SP - 1403

EP - 1407

JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

SN - 0955-3002

IS - 10

ER -