Effects of dietary AflaDetox on performance, serum biochemistry, histopathological changes, and aflatoxin residues in broilers exposed to aflatoxin B<inf>1</inf>

M. Denli, J. C. Blandon, M. E. Guynot, S. Salado, J. F. Perez

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83 Citations (Scopus)

Abstract

The aim of this study was to evaluate the ability of AflaDetox (Adiveter, Agro-Reus, Reus, Tarragona, Spain) in counteracting the deleterious effects of aflatoxin B1 (AFB1) in broiler chicks. A total of 120 Ross 308 one-day-old male broiler chicks were assigned to 8 treatments for 42 d. The experiment had a 2 × 4 factorial arrangement of treatments involving 0 and 1 mg of AFB1/kg feed and 0, 1, 2, and 5 g of AflaDetox/kg feed. Chicks were fed on the ground during the first 7 d and in cages (3 chicks/cage; 5 cages/treatment) from 7 to 42 d. Growth performance was measured from d 7 to 42 and whole-tract digestibility of gross energy and protein on d 40 to 41. Serum biochemical parameters, organ weights, histopathological examination of liver, and AFB1 residues in liver and breast muscle tissues were determined on d 42. Aflatoxin B1 significantly decreased the BW gain, feed intake, and impaired feed conversion rate (P < 0.05). The addition of AflaDetox in the contaminated diets significantly diminished the inhibitory effects of dietary AFB1 (P < 0.05) on the growth performance with no differences compared to the control diet. Feeding AFB1 alone decreased serum protein concentration, increased the serum activity of alkaline phosphatase, and caused significant increases in the relative weights of livers. Treatment with AflaDetox significantly alleviated the negative effects of AFB1 on these parameters (P < 0.05) with no effect on uncontaminated diets. Liver tissue of broilers receiving AFB1 alone had perilobular inflammation and vacuolar degeneration of hepatocytes as compared with the tissue from the control group (P < 0.05). Residues of AFB1 were detected in the liver tissues of broilers fed on the AFB1 diet (0.166 μg/kg). Supplementation of AflaDetox reduced the incidence and severity of the hepatic histopathology changes associated with aflatoxicosis and the amount of AFB1 residue in liver. In conclusion, our results showed that addition of AflaDetox may reduce the adverse effects produced by the presence of AFB1 in broiler chickens diets. © 2009 Poultry Science Association Inc.
Original languageEnglish
Pages (from-to)1444-1451
JournalPoultry Science
Volume88
DOIs
Publication statusPublished - 1 Jul 2009

Keywords

  • Adsorbent
  • Aflatoxin B 1
  • Broiler
  • Growth
  • Residue

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