Effects of chronic dysthyroidism on activity and exploration

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The aim of the present study was to determine the influence of thyroid function on the activity and exploratory behaviour of male Wistar rats. Dysthyroidism was induced by adding drugs to their drinking water from the ninth day of gestation. This method is not as stressful as daily thyroxine injections or thyroidectomy, and therefore did not affect the analysed behavioural patterns. After weaning, the drugs were administered to the young rats until the end of the experiment. Activity and exploration were measured using the Boissier test, a light-darkness test and an open-field test when they were 77 days old. In order to verify that the animals' motor capacity had not been impaired, a psychomotor battery was used. Chronic hyperthyroidism produced a significant increase in activity, but did not affect exploration. On the other hand, hypothyroidism did not affect activity, but did increase exploration. This increase in exploration was observed in activity-independent behavioural parameters, such as head dipping and glancing. © 2002 Elsevier Science Inc. All rights reserved.
Original languageEnglish
Pages (from-to)125-133
JournalPhysiology and Behavior
Publication statusPublished - 1 Jan 2002


  • Activity
  • Exploration
  • Hyperthyroidism
  • Hypothyroidism
  • Methimazole
  • Rat
  • Thyroxine

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