Effects of challenge with a virulent genotype II strain of porcine reproductive and respiratory syndrome virus on piglets vaccinated with an attenuated genotype I strain vaccine

M. Roca, M. Gimeno, S. Bruguera, J. Segalés, I. Díaz, I. J. Galindo-Cardiel, E. Martínez, L. Darwich, Y. Fang, J. Maldonado, R. March, E. Mateu

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Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is endemic in most parts of Asia, where genotype I and II strains of diverse virulence may coexist. This study evaluated the outcome of infection with a highly virulent Asian genotype II PRRSV isolate in piglets vaccinated with a genotype I vaccine. Twenty-one 3-week-old piglets were divided in three groups: Pigs in group V (n=8) were vaccinated with an attenuated genotype I commercial PRRSV vaccine, while pigs in group U (n=8) and a control group (group C; n=5) were unvaccinated; 6weeks later, pigs in groups V and U were challenged intranasally with a highly virulent strain of genotype II PRRSV (1×105 50% tissue culture infectious doses/mL), while pigs in group C received a placebo. Over a period of 21days after challenge, vaccinated pigs had significantly lower mortality (0/8 versus 2/8), fewer days of fever, a lower frequency of catarrhal bronchopneumonia, higher weight gains (13.4 versus 6.6kg) and lower levels of viraemia compared to unvaccinated challenged pigs. Immunisation with a genotype I attenuated PRRSV vaccine provided partial protection against challenge with a highly virulent genotype II strain. © 2011 Elsevier Ltd.
Original languageEnglish
Pages (from-to)92-96
JournalVeterinary Journal
Volume193
DOIs
Publication statusPublished - 1 Jul 2012

Keywords

  • Heterologous protection
  • Porcine reproductive and respiratory syndrome virus
  • Vaccination

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