Effects of acute nicotine and ethanol on medial prefrontal cortex self-stimulation in rats

Amaia Arregui-Aguirre; Francisco Claro-Izaguirre; Maria José Goñi-Garrido; Jon Andoni Zárate-Oleaga; Ignacio Morgado-Bernal

doi:10.1016/0091-3057(87)90470-9

Effects of acute nicotine and ethanol on medial prefrontal cortex self-stimulation in rats

Amaia Arregui-Aguirre, Francisco Claro-Izaguirre, Maria José Goñi-Garrido, Jon Andoni Zárate-Oleaga, Ignacio Morgado-Bernal

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

The acute effects of nicotine and ethanol were studied in low and high rates of intracranial self-stimulation (ICSS) of the medial prefrontal cortex (MPFC) in the rat. Nicotine tended to increase low ICSS rates but did not change or even reduced high ICSS rates. Independent of ICSS rate, ethanol tended to decrease ICSS, but only at high doses (1.0 g/kg). It is suggested that the effects of nicotine and ethanol on ICSS may be mediated by their effects on dopamine. © 1987.

Original language	English
Pages (from-to)	15-20
Journal	Pharmacology, Biochemistry and Behavior
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/0091-3057(87)90470-9
Publication status	Published - 1 Jan 1987

Keywords

Ethanol
Intracranial self-stimulation
Medial prefrontal cortex
Nicotine

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title = "Effects of acute nicotine and ethanol on medial prefrontal cortex self-stimulation in rats",

abstract = "The acute effects of nicotine and ethanol were studied in low and high rates of intracranial self-stimulation (ICSS) of the medial prefrontal cortex (MPFC) in the rat. Nicotine tended to increase low ICSS rates but did not change or even reduced high ICSS rates. Independent of ICSS rate, ethanol tended to decrease ICSS, but only at high doses (1.0 g/kg). It is suggested that the effects of nicotine and ethanol on ICSS may be mediated by their effects on dopamine. {\textcopyright} 1987.",

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Effects of acute nicotine and ethanol on medial prefrontal cortex self-stimulation in rats. / Arregui-Aguirre, Amaia; Claro-Izaguirre, Francisco; Goñi-Garrido, Maria José; Zárate-Oleaga, Jon Andoni; Morgado-Bernal, Ignacio.

In: Pharmacology, Biochemistry and Behavior, Vol. 27, No. 1, 01.01.1987, p. 15-20.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Goñi-Garrido, Maria José

AU - Zárate-Oleaga, Jon Andoni

AU - Morgado-Bernal, Ignacio

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KW - Intracranial self-stimulation

KW - Medial prefrontal cortex

KW - Nicotine

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