Effects of acute nicotine and ethanol on medial prefrontal cortex self-stimulation in rats

Amaia Arregui-Aguirre, Francisco Claro-Izaguirre, Maria José Goñi-Garrido, Jon Andoni Zárate-Oleaga, Ignacio Morgado-Bernal

    Research output: Contribution to journalArticleResearchpeer-review

    8 Citations (Scopus)

    Abstract

    The acute effects of nicotine and ethanol were studied in low and high rates of intracranial self-stimulation (ICSS) of the medial prefrontal cortex (MPFC) in the rat. Nicotine tended to increase low ICSS rates but did not change or even reduced high ICSS rates. Independent of ICSS rate, ethanol tended to decrease ICSS, but only at high doses (1.0 g/kg). It is suggested that the effects of nicotine and ethanol on ICSS may be mediated by their effects on dopamine. © 1987.
    Original languageEnglish
    Pages (from-to)15-20
    JournalPharmacology, Biochemistry and Behavior
    Volume27
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 1987

    Keywords

    • Ethanol
    • Intracranial self-stimulation
    • Medial prefrontal cortex
    • Nicotine

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