Effects of acute handling stress on short-term central expression of orexigenic/anorexigenic genes in zebrafish

Raul Cortés, Mariana Teles, Miguel Oliveira, Camino Fierro-Castro, Lluis Tort, José Miguel Cerdá-Reverter

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

© 2017, Springer Science+Business Media B.V. Physiological mechanisms driving stress response in vertebrates are evolutionarily conserved. These mechanisms involve the activation of both the hypothalamic-sympathetic-chromaffin cell (HSC) and the hypothalamic-pituitary-adrenal (HPA) axes. In fish, the reduction of food intake levels is a common feature of the behavioral response to stress but the central mechanisms coordinating the energetic response are not well understood yet. In this work, we explore the effects of acute stress on key central systems regulating food intake in fish as well as on total body cortisol and glucose levels. We show that acute stress induced a rapid increase in total body cortisol with no changes in body glucose, at the same time promoting a prompt central response by activating neuronal pathways. All three orexigenic peptides examined, i.e., neuropeptide y (npy), agouti-related protein (agrp), and ghrelin, increased their central expression level suggesting that these neuronal systems are not involved in the short-term feeding inhibitory effects of acute stress. By contrast, the anorexigenic precursors tested, i.e., cart peptides and pomc, exhibited increased expression after acute stress, suggesting their involvement in the anorexigenic effects.
Original languageEnglish
Pages (from-to)257-272
JournalFish Physiology and Biochemistry
Volume44
Issue number1
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • Brain
  • Cart
  • Feeding behavior
  • Food intake
  • Melanocortin
  • Npy

Fingerprint Dive into the research topics of 'Effects of acute handling stress on short-term central expression of orexigenic/anorexigenic genes in zebrafish'. Together they form a unique fingerprint.

Cite this