Effectiveness of treatments for severe sepsis: A prospective, multicenter, observational study

Ricard Ferrer, Antonio Artigas, David Suarez, Eduardo Palencia, Mitchell M. Levy, Angel Arenzana, Xose Luis Pérez, Josep Maria Sirvent

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Abstract

Rationale: Several Surviving Sepsis Campaign Guidelines recommendations are reevaluated. Objectives: To analyze the effectiveness of treatments recommended in the sepsis guidelines. Methods: In a prospective observational study, we studied all adult patients with severe sepsis from 77 intensive care units.We recorded compliance with four therapeutic goals (central venous pressure 8 mm Hg or greater for persistent hypotension despite fluid resuscitation and/or lactate greater than 36mg/dl, central venous oxygen saturation 70% or greater for persistent hypotension despite fluid resuscitation and/or lactate greater than 36 mg/dl, blood glucose greater than or equal to the lower limit of normal but less than 150 mg/dl, and inspiratory plateau pressure less than 30 cm H 2O for mechanically ventilated patients) and four treatments (early broadspectrum antibiotics, fluid challenge in the event of hypotension and/or lactate greater than 36 mg/dl, low-dose steroids for septic shock, drotrecogin alfa [activated] for multiorgan failure). The primary outcome measure was hospital mortality. The effectiveness of each treatment was estimated using propensity scores. Measurements and Main Results: Of 2,796 patients, 41.6% died before hospital discharge. Treatments associated with lower hospital mortality were early broad-spectrum antibiotic treatment (treatment within 1 hour vs. no treatment within first 6 hours of diagnosis; odds ratio, 0.67; 95% confidence interval, 0.50-0.90; P = 0.008) and drotrecogin alfa (activated) (odds ratio, 0.59; 95% confidence interval, 0.41-0.84; P = 0.004). Fluid challenge and low-dose steroids showed no benefits. Conclusions: In severe sepsis, early administration of broad-spectrum antibiotics in all patients and administration of drotrecogin alfa (activated) in the most severe patients reduce mortality.
Original languageEnglish
Pages (from-to)861-866
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume180
Issue number9
DOIs
Publication statusPublished - 1 Nov 2009

Keywords

  • Guidelines
  • Intensive care unit
  • Mortality
  • Propensity scores

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    Ferrer, R., Artigas, A., Suarez, D., Palencia, E., Levy, M. M., Arenzana, A., Pérez, X. L., & Sirvent, J. M. (2009). Effectiveness of treatments for severe sepsis: A prospective, multicenter, observational study. American Journal of Respiratory and Critical Care Medicine, 180(9), 861-866. https://doi.org/10.1164/rccm.200812-1912OC