Effectiveness and safety of psoralen-uva (PUVA) topical therapy in palmoplantar psoriasis: A report on 48 patients

J. M. Carrascosa, A. Plana, C. Ferrándiz

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17 Citations (Scopus)


Introduction: Palmoplantar psoriasis is an uncommon clinical form of psoriasis. Although localized to the palms and soles, it has a considerable impact on the patient's function and quality of life. Objectives: To study the effectiveness and safety of psoralen-UV-A (PUVA) therapy in palmoplantar psoriasis and investigate predictors of clinical response. Material and methods: We performed a retrospective chart review of all patients with palmoplantar psoriasis treated with topical PUVA therapy at our hospital between 2008 and 2011. Data were collected on effectiveness (using physician global assessment [PGA] scores), safety, and a range of clinical, epidemiological, and treatment-related variables. Results: We studied 48 patients (33 women and 15 men) with a mean age of 51 years. Treatment was considered to be effective (PGA score of 0 or 1) in 63% of cases. In addition to PUVA, systemic therapy was required in 47.9% of patients; the drug most often used was acitretin. Adverse effects were reported for 25% of patients during treatment. The most common effect was mild erythema, present in 18% of cases. Conclusions: In our experience, topical PUVA is an appropriate treatment alternative for palmoplantar psoriasis; it offers similar response rates to systemic treatments, but has a better tolerance and safety profile. Associated systemic treatment, with acitretin in most cases, improved the probability of a satisfactory response to PUVA and should be considered in patients who do not respond adequately after 8 to 10 sessions. © 2012 Elsevier España, S.L. y AEDV. Todos los derechos reservados.
Original languageEnglish
Pages (from-to)418-425
JournalActas Dermo-Sifiliograficas
Issue number5
Publication statusPublished - 1 Jan 2013


  • Acitretin
  • Palmoplantar
  • Phototherapy
  • Psoriasis
  • Ultraviolet light A plus psoralens


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