Effective multiple-solvent suppression scheme using the excitation sculpting principle

An interesting and simple approach to effective multiple-solvent suppression is proposed using the basic principles of the excitation sculpting methodology. Flat baseline and ultra-clean NMR spectra are usually obtained under standard conditions using a modified double pulsed field gradient echo scheme in samples containing mixtures of non-deuterated solvents. The simple performance of such an approach, the high tolerance to experimental mis-settings, the impressive level of solvent suppression and the easy incorporation of the proposed scheme in multi-dimensional NMR experiments make this method suitable for possible applications in liquid chromatography NMR. © 1998 John Wiley & Sons, Ltd.