Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: A randomised trial

Jordi Salas-Salvadó, Xavier Farrés, Xavier Luque, Silvia Narejos, Manel Borrell, Josep Basora, Anna Anguera, Josep Lluis Fernández, Mònica Bulló, Rafel Balanza, Mònica Bulló, Patricia Casas, Fabiola Márquez, Carles Brotons, Anna Alté, Cristina González Fernández, Ferran Torres, Manuel Prieto, Teresa Basora

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78 Citations (Scopus)

Abstract

The aim of the study was to compare the effect of the administration of a mixture of fibres on body weight-loss, satiety, lipid profile and glucose metabolism. We included 200 overweight or obese patients in a parallel, double-blind, placebo-controlled clinical trial, who were randomised to receive, in the context of an energy-restricted diet for a period of 16 weeks, a mixed fibre dose (3 g Plantago ovata husk and 1 g glucomannan) twice (b.i.d. group) or three times daily (t.i.d. group) or placebo. Weight change was the primary efficacy endpoint. Satiety, dietary compliance, lipid profile, glucose tolerance, insulin resistance and high-sensitivity C-reactive protein were secondary endpoints. Weight loss tended to be higher after both doses of fibre (-4.52 (SD 0.56) and -4.60 (SD 0.55) kg) than placebo (-0.79 (SD 0.58) kg); the differences in changes between groups were not statistically significant. Postprandial satiety increased in both fibre groups compared to the placebo. The differences between groups in LDL-cholesterol levels were significant (P = 0.03), with greater reductions in the two fibre-supplemented groups (-0.38 (SD 0.10) and -0.24 (SD 0.09) mmol/l in the b.i.d. and t.i.d. groups v. -0.06 (SD 0.09) mmol/l in placebo group). A similar pattern was observed for changes in total cholesterol:HDL-cholesterol and HDL-cholesterol:LDL-cholesterol ratios. Interventions were well tolerated and had no effects on HDL-cholesterol, glucose and insulin concentrations, glucose tolerance or high-sensitivity C-reactive protein. In conclusion, a 16-week dietary supplement of soluble fibre in overweight or obese patients was well tolerated, induced satiety and had beneficial effects on some CVD risk factors, the most important of which was a significant decrease in plasma LDL-cholesterol concentrations. © The Authors 2007.
Original languageEnglish
Pages (from-to)1380-1387
JournalBritish Journal of Nutrition
Volume99
Issue number6
DOIs
Publication statusPublished - 7 Oct 2008

Keywords

  • Body weight
  • Dietary fibre
  • Glucomannan
  • Lipid profile
  • Plantago

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