TY - JOUR
T1 - Effect of sulindac on prostaglandin excretion and renal function in cirrhotic patients with ascites
AU - Guarner, C.
AU - Enriquez, J.
AU - Guarner, F.
AU - Quiroga, J.
AU - Just, J.
AU - Seres, I.
AU - Prieto, J.
AU - Vilardell, F.
PY - 1986/1/1
Y1 - 1986/1/1
N2 - The effect of sulindac, a nonsteroidal anti-inflammatory drug, on renal prostaglandin synthesis and renal function variables was investigated in six cirrhotic patients with tense ascites and marked sodium retention. We studied serum thromboxane (TXB2) production, urinary prostaglandin excretion (6-keto-prostaglandin F1 a and TXB2) and renal function before and after administration of a therapeutic dose of sulindac (400 mg). After treatment, no significant changes were observed in urinary prostaglandin excretion, serum creatinine concentration, urine volume, or urinary sodium and creatinine clearance, whereas the serum TXB2 concentration was reduced in 89% In five patients systemic prostaglandins were inhibited, but renal excretion remained unchallenged. However, one patient showed marked reduction of urinary prostaglandins associated with a depression of renal function. The study suggests that sulindac could be a safe substitute for other nonsteroidal anti-inflammatory drugs in cirrhotic patients with ascites. Further pharmacological trials seem to be warranted. © 1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
AB - The effect of sulindac, a nonsteroidal anti-inflammatory drug, on renal prostaglandin synthesis and renal function variables was investigated in six cirrhotic patients with tense ascites and marked sodium retention. We studied serum thromboxane (TXB2) production, urinary prostaglandin excretion (6-keto-prostaglandin F1 a and TXB2) and renal function before and after administration of a therapeutic dose of sulindac (400 mg). After treatment, no significant changes were observed in urinary prostaglandin excretion, serum creatinine concentration, urine volume, or urinary sodium and creatinine clearance, whereas the serum TXB2 concentration was reduced in 89% In five patients systemic prostaglandins were inhibited, but renal excretion remained unchallenged. However, one patient showed marked reduction of urinary prostaglandins associated with a depression of renal function. The study suggests that sulindac could be a safe substitute for other nonsteroidal anti-inflammatory drugs in cirrhotic patients with ascites. Further pharmacological trials seem to be warranted. © 1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
KW - Anti-inflammatory drugs
KW - Ascites
KW - Liver cirrhosis
KW - Prostaglandins
U2 - 10.3109/00365528609034652
DO - 10.3109/00365528609034652
M3 - Article
VL - 21
SP - 231
EP - 234
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
IS - 2
ER -