Effect of sulindac on prostaglandin excretion and renal function in cirrhotic patients with ascites

C. Guarner, J. Enriquez, F. Guarner, J. Quiroga, J. Just, I. Seres, J. Prieto, F. Vilardell

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The effect of sulindac, a nonsteroidal anti-inflammatory drug, on renal prostaglandin synthesis and renal function variables was investigated in six cirrhotic patients with tense ascites and marked sodium retention. We studied serum thromboxane (TXB2) production, urinary prostaglandin excretion (6-keto-prostaglandin F1 a and TXB2) and renal function before and after administration of a therapeutic dose of sulindac (400 mg). After treatment, no significant changes were observed in urinary prostaglandin excretion, serum creatinine concentration, urine volume, or urinary sodium and creatinine clearance, whereas the serum TXB2 concentration was reduced in 89% In five patients systemic prostaglandins were inhibited, but renal excretion remained unchallenged. However, one patient showed marked reduction of urinary prostaglandins associated with a depression of renal function. The study suggests that sulindac could be a safe substitute for other nonsteroidal anti-inflammatory drugs in cirrhotic patients with ascites. Further pharmacological trials seem to be warranted. © 1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Original languageEnglish
Pages (from-to)231-234
JournalScandinavian Journal of Gastroenterology
Volume21
Issue number2
DOIs
Publication statusPublished - 1 Jan 1986

Keywords

  • Anti-inflammatory drugs
  • Ascites
  • Liver cirrhosis
  • Prostaglandins

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