Effect of sucralfate on gastric: Intramucosal pH in critically ill patients

X. Calvet, F. Baigorri, M. Duarte, D. Joseph, P. Saura, A. Mas, C. Royo, A. Artigas

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14 Citations (Scopus)


Objective: To determine whether sucralfate administration affects the tonometric measurement of gastric intramucosal pH (pHi). Design: Non-randomized observational study. Setting: General intensive care unit of a teaching hospital. Patients: Twenty critically ill, mechanically ventilated, consecutively admitted patients requiring an arterial catheter and nasogastric tube. Interventions: Tonometer placement and sucralfate administration. Measurements and main results: We simultaneously determined tonometer saline PCO2 (PCO2i), arterial blood gases, pH of gastric juice and pHi. These parameters were evaluated immediately before sucralfate administration, and 2 h and 4 h after. We did not detect any change in either PCO2i or pHi after sucralfate administration (PCO2i: basal 6.4 ± 1.7, 2 h 6.3 ± 1.7, 4 h 6.3 ± 1.7; pHi: basal 7.35 ± 0.13, 2 h 7.36 ± 0.12, 4 h 7.36 ± 0.12). Conclusions: Sucralfate does not affect the tonometric measurement of PCO2i and pHi.
Original languageEnglish
Pages (from-to)738-742
JournalIntensive Care Medicine
Issue number7
Publication statusPublished - 22 Sep 1997


  • Critically ill patients
  • Gastric intramucosal pH
  • Sucralfate
  • Tonometry


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