Effect of statin and fibrate treatment on inflammation in type 2 diabetes. A randomized, cross-over study

Ana María Wägner, Jose Luis Sánchez-Quesada, Sonia Benítez, Cristina Bancells, Jordi Ordóñez-Llanos, Antonio Pérez

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Abstract

A randomized, crossover study compared the effects of atorvastatin, gemfibrozil and their combination on inflammatory markers in type 2 diabetes. C-reactive protein (CRP), lipoprotein-associated phospholipase A2 (Lp-PLA2), secretory phospholipase A2 (sPLA2), interleukin 8 (IL8), monocyte chemotactic protein 1 (MCP1) and tumor necrosis factor α (TNFα) were measured. Both lipid-lowering drugs had positive, complementary and additive effects on inflammatory markers, which were closely related to baseline inflammatory status. © 2011 Elsevier Ireland Ltd.
Original languageEnglish
JournalDiabetes Research and Clinical Practice
Volume93
Issue number1
DOIs
Publication statusPublished - 1 Jul 2011

Keywords

  • Atorvastatin
  • C-reactive protein
  • Gemfibrozil
  • Inflammation markers
  • Phospholipase A2

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    Wägner, A. M., Sánchez-Quesada, J. L., Benítez, S., Bancells, C., Ordóñez-Llanos, J., & Pérez, A. (2011). Effect of statin and fibrate treatment on inflammation in type 2 diabetes. A randomized, cross-over study. Diabetes Research and Clinical Practice, 93(1). https://doi.org/10.1016/j.diabres.2011.03.009