TY - JOUR
T1 - Effect of olive oil phenolic compounds on the expression of blood pressure-related genes in healthy individuals
AU - Martín-Peláez, Sandra
AU - Castañer, Olga
AU - Konstantinidou, Valentini
AU - Subirana, Isaac
AU - Muñoz-Aguayo, Daniel
AU - Blanchart, Gemma
AU - Gaixas, Sonia
AU - de la Torre, Rafael
AU - Farré, Magí
AU - Sáez, Guillermo T.
AU - Nyyssönen, Kristina
AU - Zunft, Hans Joachim
AU - Covas, Maria Isabel
AU - Fitó, Montse
PY - 2017/3/1
Y1 - 2017/3/1
N2 - © 2015, Springer-Verlag Berlin Heidelberg. Purpose: To investigate whether the ingestion of olive oil having different phenolic contents influences the expression of blood pressure-related genes, involved in the renin–angiotensin–aldosterone system, in healthy humans. Methods: A randomized, double-blind, crossover human trial with 18 healthy subjects, who ingested 25 mL/day of olive oils (1) high (366 mg/kg, HPC) and (2) low (2.7 mg/kg, LPC) in phenolic compounds for 3 weeks, preceded by 2-week washout periods. Determination of selected blood pressure-related gene expression in peripheral blood mononuclear cells (PBMNC) by qPCR, blood pressure and systemic biomarkers. Results: HPC decreased systolic blood pressure compared to pre-intervention values and to LPC, and maintained diastolic blood pressure values compared to LPC. HPC decreased ACE and NR1H2 gene expressions compared with pre-intervention values, and IL8RA gene expression compared with LPC. Conclusions: The introduction to the diet of an extra-virgin olive oil rich in phenolic compounds modulates the expression of some of the genes related to the renin–angiotensin–aldosterone system. These changes could underlie the decrease in systolic blood pressure observed.
AB - © 2015, Springer-Verlag Berlin Heidelberg. Purpose: To investigate whether the ingestion of olive oil having different phenolic contents influences the expression of blood pressure-related genes, involved in the renin–angiotensin–aldosterone system, in healthy humans. Methods: A randomized, double-blind, crossover human trial with 18 healthy subjects, who ingested 25 mL/day of olive oils (1) high (366 mg/kg, HPC) and (2) low (2.7 mg/kg, LPC) in phenolic compounds for 3 weeks, preceded by 2-week washout periods. Determination of selected blood pressure-related gene expression in peripheral blood mononuclear cells (PBMNC) by qPCR, blood pressure and systemic biomarkers. Results: HPC decreased systolic blood pressure compared to pre-intervention values and to LPC, and maintained diastolic blood pressure values compared to LPC. HPC decreased ACE and NR1H2 gene expressions compared with pre-intervention values, and IL8RA gene expression compared with LPC. Conclusions: The introduction to the diet of an extra-virgin olive oil rich in phenolic compounds modulates the expression of some of the genes related to the renin–angiotensin–aldosterone system. These changes could underlie the decrease in systolic blood pressure observed.
KW - Blood pressure
KW - Nutrigenomics
KW - Olive oil
KW - Phenolic compounds
KW - RAAS
U2 - 10.1007/s00394-015-1110-z
DO - 10.1007/s00394-015-1110-z
M3 - Article
SN - 1436-6207
VL - 56
SP - 663
EP - 670
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 2
ER -
