Effect of OcraTox on the performance and egg quality of laying hens exposed to ochratoxin A

Muzaffer Denli, Juan Carlos Blandón Martínez, Maria Elena Guynot, S. Salado, Jose Francisco Perez Hernandez

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An experiment was conducted to evaluate the efficacy of a new ochratoxin-binding agent (OcraTox, 5 g/kg of feed) in offsetting the toxic effects of
ochratoxin A (OTA, 2 mg/kg of feed) in laying hen diets. Performance, serum biochemistry, OTA residue in the liver and eggs, and egg quality parameters were evaluated. Twenty-eight Hisex Brown laying hens, 47 wk of age, were allocated to 1 of 4 experimental treatments for 3 wk: control, OTA (containing 2 mg of OTA/kg of feed), OcraTox (containing 5 g of OcraTox/kg of feed), and OTA + OcraTox (containing 2 mg of OTA and 5 g of OcraTox/kg of feed). Laying hens fed OcraTox showed results similar to the control hens (P > 0.05). The OTA
diet significantly (P < 0.05) reduced daily feed consumption, egg mass production, and serum triglyceride
concentrations, and increased the relative liver weight,
the serum activity of alkaline phosphatase, and the serum concentration of uric acid as compared with the
control diet. Addition of OcraTox to the contaminated
diet alleviated (P < 0.05) the negative effects resulting
from OTA, reaching values not significantly different
from the control diet for most of the parameters except the relative weight of the liver. Birds fed the OTA
treatment showed a greater content of OTA in the liver
(15.1 μg/kg) than those fed the control diet (kg). Supplementing the contaminated diet with OcraTox (OTA + OcraTox) reduced the values to 12.0 μg/kg.
Residues of OTA were not detected above our detection
limit (0.05 μg/kg) in any of the analyzed eggs. In conclusion, our results indicated that addition of OcraTox
can counteract the deleterious effects caused by OTA
in laying hens.
Original languageEnglish
JournalPoultry Science
Publication statusPublished - 2007


  • Binding agent
  • Egg quality
  • Laying hen
  • Ochratoxin A
  • Performance


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