Effect of neuropeptide Y on α<inf>2</inf>-adrenoceptor-mediated cardiovascular responses in the pithed rat

E. Vila, I. M. Macrae

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    9 Citations (Scopus)

    Abstract

    The effects of neuropeptide Y (NPY) on the cardiovascular responses induced by stimulation of pre- and postjunctional α2-adrenoceptors were studied in the pithed normotensive rat. The increase in diastolic blood pressure induced by cumulative injection of xylazine (1 - 1000 μg kg-1, i.v.) were potentiated by NPY (5 μg kg-1) but not affected by a lower dose (0.75 μg kg-1) of this peptide. Xylazine (1 - 100 μg kg-1) inhibited in a dose-dependent manner the tachycardia induced by continuous electrical stimulation (0.2 Hz, 2 ms, 60 V) of the spinal cord (C7-Thl). NPY (5 μg kg-1 but not 0.75 μg kg-1) enhanced the inhibitory effect of xylazine on the tachycardia induced by electrical stimulation without having any direct effect on heart rate. These results suggest that there may be a positive interaction between NPY receptors, postjunctional α2-adrenoceptors and between NPY receptors and prejunctional α2-adrenoceptors in the cardiovascular system of the rat.
    Original languageEnglish
    Pages (from-to)840-842
    JournalBritish Journal of Pharmacology
    Volume100
    Issue number4
    DOIs
    Publication statusPublished - 1 Jan 1990

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