Effect of nepafenac on the foveal profile of glaucomatous patients undergoing phacoemulsification

Elena Milla*, Oana Stirbu, Isabel Jimenez Franco, Santiago J.García Hernández, Jose Rios, Susana Duch

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review


Purpose: Retrospective, pilot study to determine whether nepafenac treatment pre- and postcataract surgery in glaucoma patients using topical hypotensive agents minimized cystoid macular edema by comparing pre- and postsurgical foveal characteristics, as in some cases these agents cannot be withdrawn and, hypothetically, their inflammatory effect on the fovea could be neutralized by the addition of nepafenac. Methods: Patients were divided into two subgroups depending on whether or not topical nepafenac was added to the surgical protocol (NEP = nepafenac group and nNEP = non nepafenac group). All had undergone phacoemulsification and data on pre- and postoperative macular status were recorded. Results: In the nNEP group, there was a significant increase in foveal thickness (FT) in the first month postoperative visit with respect to the preoperative status (p = 0.006), and this situation did not change at the third postoperative month (p = 0.9411). In the NEP group, the increase in FT was not significant at the first month after surgery (p = 0.056) nor at the final visit (p = 0.268), in contrast to the nNEP group. Conclusion: This study of the possible prophylactic effect of nepafenac on postoperative macular edema supports the results of other studies that confirm subclinical edema post phacoemulsification, and found a significantly lower gradient in the increase in FT in patients treated pre- and postoperatively with nepafenac.

Original languageAmerican English
Pages (from-to)1147-1153
Number of pages7
JournalInternational Ophthalmology
Issue number5
Publication statusPublished - 1 Oct 2017


  • Cystoid macular edema
  • Hypotensive drugs
  • Nepafenac
  • Preservatives
  • Pseudophakic maculopathy


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