Effect of marbofloxacin on Haemophilus parasuis nasal carriage

Carles Vilalta, Nuria Galofré, Virginia Aragon, Ana María Pérez de Rozas, Lorenzo Fraile

    Research output: Contribution to journalArticleResearchpeer-review

    7 Citations (Scopus)

    Abstract

    Haemophilus parasuis is a colonizer of the upper respiratory tract and the causative agent of Glässer's disease in swine. This study focused on the nasal carriage of H. parasuis after treatment with marbofloxacin. Three marbofloxacin treatments (three doses of 2. mg/kg body weight [bw] every 24. h, two doses of 4. mg/kg bw every 48. h and 8. mg/kg bw in one single shot) were used and all of them reduce significantly (p< 0.05) the nasal carriage of H. parasuis as compared to control animals. Moreover, H. parasuis was not detected in the nasal cavities of piglets after administering the highest dose. The effect of a dose of 8. mg marbofloxacin/kg bw in one shot was further studied in a farm with clinical cases of Glässer's disease using a longitudinal study. Statistically significant reduction of nasal carriage of H. parasuis was detected during the first week after treatment in comparison with the control group. However, a clear relationship between the minimum inhibitory concentration (MIC) of the different strains, their putative virulence or the treatment group (antibiotic or control) from which they were isolated was not detected. Finally, the effect induced by the antibiotic treatment on the bacterial strains seemed to be transitory, since diverse H. parasuis strains (with high and low marbofloxacin MICs) were observed 7. days after finishing the treatment. © 2012 Elsevier B.V..
    Original languageEnglish
    Pages (from-to)123-129
    JournalVeterinary Microbiology
    Volume159
    Issue number1-2
    DOIs
    Publication statusPublished - 14 Sep 2012

    Keywords

    • Antimicrobial treatment
    • Carriage
    • Fluoroquinolones
    • Haemophilus parasuis

    Fingerprint Dive into the research topics of 'Effect of marbofloxacin on Haemophilus parasuis nasal carriage'. Together they form a unique fingerprint.

    Cite this