Effect of maraviroc intensification on HIV-1-specific T cell immunity in recently HIV-1-infected individuals

Ai Kawana-Tachikawa, Josep M. Llibre, Isabel Bravo, Roser Escrig, Beatriz Mothe, Jordi Puig, Maria C. Puertas, Javier Martinez-Picado, Julia Blanco, Christian Manzardo, Jose M. Miro, Aikichi Iwamoto, Anton L. Pozniak, Jose M. Gatell, Bonaventura Clotet, Christian Brander, M. Massanella, M. Ruiz-Riol, V. Bach, T. PumarolaM. Plana, M. C. Ligero, T. Gallart, Josep M. Llibre

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Background: The effect of maraviroc on the maintenance and the function of HIV-1-specific T cell responses remains unknown. Methods: Subjects recently infected with HIV-1 were randomized to receive anti-retroviral treatment with or without maraviroc intensification for 48 weeks, and were monitored up to week 60. PBMC and in vitro-expanded T cells were tested for responses to the entire HIV proteome by ELISpot analyses. Intracellular cytokine staining assays were conducted to monitor the (poly)-functionality of HIV-1-specific T cells. Analyses were performed at baseline and week 24 after treatment start, and at week 60 (3 months after maraviroc discontinuation). Results: Maraviroc intensification was associated with a slower decay of virus-specific T cell responses over time compared to the non-intensified regimen in both direct ex-vivo as well as in in-vitro expanded cells. The effector function profiles of virus-specific CD8+ T cells were indistinguishable between the two arms and did not change over time between the groups. Conclusions: Maraviroc did not negatively impact any of the measured parameters, but was rather associated with a prolonged maintenance of HIV-1-specific T cell responses. Maraviroc, in addition to its original effect as viral entry inhibitor, may provide an additional benefit on the maintenance of virus-specific T cells which may be especially important for future viral eradication strategies. © 2014 Kawana-Tachikawa et al.
Original languageEnglish
Article numbere87334
JournalPLoS ONE
Issue number1
Publication statusPublished - 27 Jan 2014


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