Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4+ T cells of antiretroviral therapy suppressed patients

Maria C. Puertas, Maria Salgado, Sara Morón López, Dan Ouchi, Jose A. Muñoz-Moreno, José Moltó, Bonaventura Clotet, Javier Martinez-Picado

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Previous in-vitro data pointed out lithium, an activator of the β-catenin signalling pathway, as a modulator of HIV-1 transcription. We assessed the effect of in-vivo administration of lithium on viral latency modulation in nine antiretroviral therapy (ART)-suppressed HIV-1-infected individuals. We found that lithium carbonate treatment was able to transiently repress HIV-1 residual expression in CD4+ T cells in vivo, which led to a concomitant short-term decrease in the proviral reservoir size. © 2014 Wolters Kluwer Health.
Original languageEnglish
Pages (from-to)2157-2159
JournalAIDS
Volume28
Issue number14
DOIs
Publication statusPublished - 1 Jan 2014

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