TY - JOUR
T1 - Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4+ T cells of antiretroviral therapy suppressed patients
AU - Puertas, Maria C.
AU - Salgado, Maria
AU - López, Sara Morón
AU - Ouchi, Dan
AU - Muñoz-Moreno, Jose A.
AU - Moltó, José
AU - Clotet, Bonaventura
AU - Martinez-Picado, Javier
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Previous in-vitro data pointed out lithium, an activator of the β-catenin signalling pathway, as a modulator of HIV-1 transcription. We assessed the effect of in-vivo administration of lithium on viral latency modulation in nine antiretroviral therapy (ART)-suppressed HIV-1-infected individuals. We found that lithium carbonate treatment was able to transiently repress HIV-1 residual expression in CD4+ T cells in vivo, which led to a concomitant short-term decrease in the proviral reservoir size. © 2014 Wolters Kluwer Health.
AB - Previous in-vitro data pointed out lithium, an activator of the β-catenin signalling pathway, as a modulator of HIV-1 transcription. We assessed the effect of in-vivo administration of lithium on viral latency modulation in nine antiretroviral therapy (ART)-suppressed HIV-1-infected individuals. We found that lithium carbonate treatment was able to transiently repress HIV-1 residual expression in CD4+ T cells in vivo, which led to a concomitant short-term decrease in the proviral reservoir size. © 2014 Wolters Kluwer Health.
U2 - 10.1097/QAD.0000000000000374
DO - 10.1097/QAD.0000000000000374
M3 - Article
VL - 28
SP - 2157
EP - 2159
IS - 14
ER -
